E4MQ50 · E4MQ50_CAPOC
- ProteinPutative K(+)-stimulated pyrophosphate-energized sodium pump
- Geneppa
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids919 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.
Catalytic activity
- Na+(in) + diphosphate + H2O = Na+(out) + 2 phosphate + H+Na+ (in)CHEBI:29101
+ CHEBI:33019 + CHEBI:15377 = Na+ (out)CHEBI:29101+ 2 CHEBI:43474 + CHEBI:15378
Cofactor
Activity regulation
Requires K+ for maximal activity.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 498 | Determinant of potassium dependence | ||||
Sequence: A |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | potassium ion binding | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative K(+)-stimulated pyrophosphate-energized sodium pump
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Capnocytophaga
Accessions
- Primary accessionE4MQ50
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endomembrane system ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-27 | Helical | ||||
Sequence: LYLPLALAIFGLIFMITKALWV | ||||||
Transmembrane | 58-77 | Helical | ||||
Sequence: ILALFVIIASIALFIVSRMV | ||||||
Transmembrane | 83-106 | Helical | ||||
Sequence: LIVVAFVCGAFFSALAGNIGMRIA | ||||||
Transmembrane | 127-155 | Helical | ||||
Sequence: VSFGGGTVMGLGVAGLAVLGLSLFFILFV | ||||||
Transmembrane | 245-263 | Helical | ||||
Sequence: FGSYVATVLASMVLGNYVI | ||||||
Transmembrane | 284-306 | Helical | ||||
Sequence: ILLPLVIAGVGIIASIIGTFCIG | ||||||
Transmembrane | 326-344 | Helical | ||||
Sequence: YVALGLTLVACFFLIKYML | ||||||
Transmembrane | 365-383 | Helical | ||||
Sequence: VFYATIVGLAVGLLISAIT | ||||||
Transmembrane | 424-447 | Helical | ||||
Sequence: VLLFAVAIWGSYSLAGFYGVAIAA | ||||||
Transmembrane | 504-523 | Helical | ||||
Sequence: FAIASAALTALALFAAYVTF | ||||||
Transmembrane | 535-555 | Helical | ||||
Sequence: NVLAALFIGGMIPVIFSALAM | ||||||
Transmembrane | 603-620 | Helical | ||||
Sequence: MMLPGAITIITPIIIGFV |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 802-919 | OmpA-like | ||||
Sequence: QFKDNWITLDRTYFKTGSDELTEGSEQQLKNIVAILKAYPKAAIRLGGYTDNTGSVEGNKKLSERRANSVLNKLVALGANKAQLSAQGYGAEHPLCPANDTPECKAKNRRIDIRLTAK |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length919
- Mass (Da)96,489
- Last updated2011-02-08 v1
- Checksum4DA06EB86B5D78C1