E3ZMB4 · E3ZMB4_LISSE
- ProteinHeme-degrading monooxygenase
- GeneisdG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids121 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
Catalytic activity
- heme b + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = biliverdin IXalpha + CO + Fe2+ + 3 oxidized [NADPH--hemoprotein reductase] + 3 H2O + H+
Features
Showing features for binding site, site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | heme binding | |
Molecular Function | heme oxygenase (decyclizing) activity | |
Molecular Function | iron ion binding | |
Biological Process | heme catabolic process | |
Biological Process | iron import into cell |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHeme-degrading monooxygenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Listeria
Accessions
- Primary accessionE3ZMB4
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-101 | ABM | ||||
Sequence: IIVTNTIKVEKGAAEHVIRQFTGENGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSFKKAHGRTKDSRAQREDRKGIV | ||||||
Region | 76-98 | Disordered | ||||
Sequence: KSDSFKKAHGRTKDSRAQREDRK |
Sequence similarities
Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length121
- Mass (Da)13,829
- Last updated2011-02-08 v1
- ChecksumD28FE74BF218C7CA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ADXJ01000223 EMBL· GenBank· DDBJ | EFS01225.1 EMBL· GenBank· DDBJ | Genomic DNA |