E3ZMB4 · E3ZMB4_LISSE

Function

function

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, site.

1121102030405060708090100110120
TypeIDPosition(s)Description
Binding site6Fe cation (UniProtKB | ChEBI)
Site74Transition state stabilizer
Binding site84Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionheme binding
Molecular Functionheme oxygenase (decyclizing) activity
Molecular Functioniron ion binding
Biological Processheme catabolic process
Biological Processiron import into cell

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme-degrading monooxygenase
  • EC number
  • Alternative names
    • Heme oxygenase
    • Iron-regulated surface determinant
    • Iron-responsive surface determinant

Gene names

    • Name
      isdG
    • ORF names
      NT03LS_0564

Organism names

Accessions

  • Primary accession
    E3ZMB4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain2-101ABM
Region76-98Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    121
  • Mass (Da)
    13,829
  • Last updated
    2011-02-08 v1
  • Checksum
    D28FE74BF218C7CA
MIIVTNTIKVEKGAAEHVIRQFTGENGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSFKKAHGRTKDSRAQREDRKGIVGNEIARFEVVHVQNPVVIEK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADXJ01000223
EMBL· GenBank· DDBJ
EFS01225.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp