E3ZM36 · E3ZM36_LISSE

Function

function

Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. Is involved in a myo-inositol catabolic pathway. Bicarbonate, and not CO2, is the end-product of the enzymatic reaction.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site150NAD+ (UniProtKB | ChEBI)
Binding site152NAD+ (UniProtKB | ChEBI)
Binding site176NAD+ (UniProtKB | ChEBI)
Binding site179NAD+ (UniProtKB | ChEBI)
Binding site180NAD+ (UniProtKB | ChEBI)
Binding site251NAD+ (UniProtKB | ChEBI)
Active site284Nucleophile
Binding site382NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmalonate-semialdehyde dehydrogenase (acetylating) activity
Molecular Functionmethylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Biological Processinositol catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malonate-semialdehyde dehydrogenase
  • EC number
  • Short names
    MSA dehydrogenase
  • Alternative names
    • Methylmalonate semialdehyde dehydrogenase
      (MMSA dehydrogenase
      ; MSDH
      )

Gene names

    • Name
      iolA
    • ORF names
      NT03LS_0481

Organism names

Accessions

  • Primary accession
    E3ZM36

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-477Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    53,442
  • Last updated
    2011-02-08 v1
  • Checksum
    6D46D5D57EF380DD
MTKVRKIKNYVNGEWVASKTEKYENVINPATGEILCQVPISTRAELDEAAEISEKAFEKWSQVAVPRRARILFSFQQLLIQHKEELARLITLENGKNLSEARGEVQRGIENVEFAAGAPTLMMGDSLASIATDVEAANYRYPVGVVGGIAPFNFPMMVPCWMFPIAIALGNSFILKPSERTPLLMEKLVELFTEAGLPNGVFNVVYGAHDVVNGILKNDKIKAVSFVGSKPVGEYVYKTGSANLKRVQALTGAKNHTIVLNDADLEDTVINVISAAFGSAGERCMACAVVTVEEGIADEFLEALRIAARNVKIGNGLDDGVFLGPVIREENQKRTLAYIEKGVEEGAKLTVDGRETGISKGHFVGPTILEEVTTDMTIWKEEIFAPVLSVIRVKNLQEAVKIANKSEFANGACIFTNNAKAIRYFREKIDAGMLGVNLGVPAPMAFFPFSGWKSSFYGTLHANGKDSVDFYTHKKVVTARYSLKGYEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADXJ01000195
EMBL· GenBank· DDBJ
EFS01311.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp