E3VXA8 · E3VXA8_9DEIO

  • Protein
    DNA polymerase IV
  • Gene
    dinB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site10Mg2+ (UniProtKB | ChEBI)
Site15Substrate discrimination
Binding site104Mg2+ (UniProtKB | ChEBI)
Active site105

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CC-FR2-10
  • Taxonomic lineage
    Bacteria > Deinococcota > Deinococci > Deinococcales > Deinococcaceae > Deinococcus

Accessions

  • Primary accession
    E3VXA8

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-187UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    358
  • Mass (Da)
    39,057
  • Last updated
    2011-01-11 v1
  • Checksum
    9849EBE987C65829
MLMRKIVHVDADAFFASVELRDNPSLRGKAVAVAYHGPRSVVTTATYEARQYGVRSALPLRTALARCPHLIVIEPRMDAYREASRLIHGVFTEFTDLIEPLSLDEAYLDVTRPKRGPGSATRIAQEIRRLVRERTGGLTVSAGVSFNKMLAKLGSGMNKPDGLTVILPQDADALIARLPVGEFYGIGPVTAAKLERLGIRTGADLRARSLTELTAAFGRHGAHMYAIARGIDDRPVDPSDDRKSVGTEDTYDTDLRTLADMHAKLPGLSERTARRLARHGLAGRVVTVKVKFSNFEVISRQQSLPVPVQTAEEIGRVARRLLGADLVGTRAVRLLGVTVSHLVDPQGRDVVPPLFPLV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ328500
EMBL· GenBank· DDBJ
ADO33729.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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