E3VS03 · E3VS03_MOUSE
- ProteinCalcium-activated potassium channel subunit alpha-1
- GeneKcnma1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1142 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- K+(in) = K+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | potassium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCalcium-activated potassium channel subunit alpha-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE3VS03
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-43 | Helical | ||||
Sequence: RMWWAFLASSMVTFFGGLFIILLW | ||||||
Transmembrane | 114-132 | Helical | ||||
Sequence: VLVVLVFALSIGALVIYFI | ||||||
Transmembrane | 152-170 | Helical | ||||
Sequence: IDMAFNVFFLLYFGLRFIA | ||||||
Transmembrane | 235-256 | Helical | ||||
Sequence: LVNLLSIFISTWLTAAGFIHLV | ||||||
Transmembrane | 271-290 | Helical | ||||
Sequence: ALTYWECVYLLMVTMSTVGY | ||||||
Transmembrane | 302-320 | Helical | ||||
Sequence: LFMVFFILGGLAMFASYVP |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 116-331 | Ion transport | ||||
Sequence: VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKK | ||||||
Domain | 341-458 | Calcium-activated potassium channel slowpoke-like RCK | ||||
Sequence: GRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIIT | ||||||
Domain | 481-568 | Calcium-activated potassium channel BK alpha subunit | ||||
Sequence: DDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAI | ||||||
Region | 644-693 | Disordered | ||||
Sequence: DPFMHKNATPNSPHVPKPVEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMR | ||||||
Compositional bias | 672-690 | Polar residues | ||||
Sequence: PKKKQRNGGMRNSPNTSPK | ||||||
Domain | 744-867 | Calcium-activated potassium channel slowpoke-like RCK | ||||
Sequence: LSGHVVVCIFGGVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGV | ||||||
Domain | 962-1082 | Ca2+-activated K+ channel Slowpoke-like C-terminal | ||||
Sequence: ILTLIRTLVTGGATPELKALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLM | ||||||
Compositional bias | 1092-1123 | Polar residues | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRPN | ||||||
Region | 1092-1142 | Disordered | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNRKEMVYR | ||||||
Compositional bias | 1124-1142 | Basic and acidic residues | ||||
Sequence: RPKSRESRDKQNRKEMVYR |
Sequence similarities
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,142
- Mass (Da)128,511
- Last updated2011-01-11 v1
- Checksum5C86CC516DC8865C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 672-690 | Polar residues | ||||
Sequence: PKKKQRNGGMRNSPNTSPK | ||||||
Compositional bias | 1092-1123 | Polar residues | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRPN | ||||||
Compositional bias | 1124-1142 | Basic and acidic residues | ||||
Sequence: RPKSRESRDKQNRKEMVYR |