E3TIK4 · E3TIK4_DOBV

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell perinuclear region of cytoplasm
Molecular Functionendonuclease activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological Processcap snatching
Biological ProcessDNA-templated transcription
Biological Processviral RNA genome replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase L
  • EC number
  • Alternative names
    • Large structural protein
    • Replicase
    • Transcriptase

Gene names

    • Name
      L

Organism names

Accessions

  • Primary accession
    E3TIK4

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain956-1142RdRp catalytic

Sequence similarities

Belongs to the Bunyavirales RNA polymerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,151
  • Mass (Da)
    246,347
  • Last updated
    2011-01-11 v1
  • Checksum
    92A5549DF0BC6045
MEKYREIHRDLQSFPVGSLTAVECIDYLDRLYAIRHDIVDQMIKHDWSDNKDSEESIGKVLLFAGVPNNVITAMEKKIIPDHPSGKTLRSFFKMTPDNYKITGSTIEFVEVTVTADVDKGIREKKLKYEAGLNYIEQELHNHFLKGDIPQPYKITFQVVSVRTDGSNISTQWPSRRNDGVVQYMRLVQAEISYVREHLIRQEERAALEAMFNLKFNISNVKNQPYYIPDYRGIALIHPNINDLVVYMKNWLSKSHKFSFHEVKGPAVFDCFNENEIEHAVKYPISRHPRNFLLIQCSLLSSYSPATILSDQVDSRRACNFVLNLIPETPTSFLIHDMAYRYINLTREDMVSFYAPKTQFVPTQNVKEPGTFKLTANSMRPESKAMLDMLGSHEPGEKKGALIESLNLSSHIVQSECVSLITKILSDLELNISEPTSHGSFTTKHTYVDNVLDKFFQNEIQRYLLDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSIHAFNNGNVILFILPSKSLEVAGSYIRFVTVFRMGPGLVDKDNLDTILTDQDVTWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQHAIRSIFAYHLLLAVCQKMKLCAIFDNLRYLIPAVTSLYSGFPSLINKLFERPFKSALEVYVYYNIKSLLVALAQNNKARFYSKVKLLGLTVDQSTVGASGIYPSFMSRVIYKHYRSLISEVTTCFFLFEKGLHGNMNEEAKIHLETVEWALKFRQKEEQYGESMVENGYTIGELNDNQDLVEQQLYCQDAVELAAVELNKILSTKSQVVANSILNKYWEVPYFSQTRNISLKGMSGQVQEDGHLAASVTIIEAIRYLSSSQNNPNVLQLYEETRKIKAQARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAISKNVAEEYISYGGERKILCIQSALEKALRWASGESFIELSNGKFIRMKRKLMYVSADATKWSPGDNSAKFRRFTAALHNGLPDDRLRNCVIDALRNVYKTDFYMSRKLRAYIDNMNGHEPAVKNFLEFFPDGHCGEVRGNWLQGNLNKCSSLFGVGMSLLFKQLWNELFPELDCFFEFAHHSDDALFIYGYLEPIDDGTDWFLYVSQQIQAGNLHWFSVNTEMWKSMFNLHEHVLLLGSIKISPKKTTLSPTNAEFLSTFFEGCAVSIPFIKILLGSLSDLPGLGYFDDLAAAQSRCVKAMDLGASPQVAQLAVALCTNKVERLYGTAVGMINHPSTYLQVKHADTPIPLGGSGAMSIMELATAGIGMSDKNLLKRALLGYLHKRQKNMAYILGLFKFLMNLSKDTFQHERLGEFSFVGKVQWKIFIPKSEFEFFDMYTPKFLKLWSEQHVTYDYIIPKGRDNLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCKLDDNWVTFREVLAAANSYAQSYEVTQEDLDLFQTLTSCTFSKEYAWKDFLNGVQCDVIPTKQIQRAKVARTFTVREKDQIIQNSIPAVIGYKFAVTVDEMSDVLDSAKFPDSLAVDLKTMKDGVYRELGLDISQAEVMKKVAPMLYKSSKSRVVIVQGNVEGTAEAICGYWLRTMSLVKTIRVKPHKEVLKAVSIFNRKEDIGQQKDLAALRLCIEVWRWCKANNAPYHEWFHALWFEDKTFSEWLDRFIRIGVPPVDPEIQCAALMIADIRGDLSVLQVQANRRAYSGKQYDAYCIQTYNEETKLYEGDLRVTFNFGLDCARLEIFWDKQTYVLETSITQKHVLKIMMDEVTKELLRCGMRFKTEQVSNVKHLVLFKTEAGFEWGKPNIPCIVYKNCALRTGLRTNQTINHKFMISIKDNGLRAIAQYDDESPRFLLAHAFHTIRDIRYQAVDAVSNVWFIHKGIKLFLNPIISSGLLENFMKNLPAAIPPAAYSLIMNRAKISVDLFMFNDLLRLINPSNTLDLSGLQPTEEGFSTVSGLSSRLWSEEVSFVDEDEEIDDEFTIDLQDVDFENIDVEADIEHFLQDESSYTGDLLIMSEETEVKKMRGIIKLLEPVRLIKSWVSKGLCIEKVYSPTNIILMTRYLSKNFNFSGKQVSLLDPYDLTEFESIVKGWGECVVDQFSTFDQEAQLLVSQKGICPEDVVPDSLFSFRHTIVLLRRLFPQDSVSTFY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU904040
EMBL· GenBank· DDBJ
ADP21255.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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