E3QYP0 · AMPP3_COLGM

Function

function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.

Catalytic activity

  • Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
    EC:3.4.11.9 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site.

146150100150200250300350400450
TypeIDPosition(s)Description
Binding site257Mn2+ 2 (UniProtKB | ChEBI)
Binding site268Mn2+ 1 (UniProtKB | ChEBI)
Binding site268Mn2+ 2 (UniProtKB | ChEBI)
Binding site391Mn2+ 1 (UniProtKB | ChEBI)
Binding site431Mn2+ 1 (UniProtKB | ChEBI)
Binding site431Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable Xaa-Pro aminopeptidase PEPP
  • EC number
  • Alternative names
    • Aminoacylproline aminopeptidase
    • Prolidase

Gene names

    • Name
      PEPP
    • ORF names
      GLRG_11122

Organism names

Accessions

  • Primary accession
    E3QYP0

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004118711-461Probable Xaa-Pro aminopeptidase PEPP

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M24B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    461
  • Mass (Da)
    51,662
  • Last updated
    2011-01-11 v1
  • Checksum
    2DEBD8E93DD6D198
MTQDYETVLKGKYPAKEHALRVADYVKSKVPDATGILYVEGRMTKMLEDNDEPEPFRQRRYFYYLTGCPLADCHYIFDLATSKSTLFIPPIDPDSVIWSGLPVSAAEAKELYDVDEVKYTTDVNAELARLGKGPKKTVFAIQNQVLDSITFLEFDEKNFSILKDAIERCRVVKDDYEIALTRKANAVSTVAHHAVVEYVKKAKNERELEALFLQRSVANGAKNQAYHGIFAGGRAAATLHYVANDAPLEGKLNLLLDAGTEWNCYASDITRTFPISGKFSKESRQIYDIVLKMQLETTAALKEGVIWDEIHLLAHKIAIDGLHLIGILKGDKDEILKNRTSVAFFPHGLGHYLGMDTHDVGGNANYADRDPMFRYLRVRGALPAGSIVTVEPGIYFCSFIIEPYLKDPVHSKFIDSAVLEKYWDVGGVRIEDNILITKDGSENLTPTIKDPDELEKIIQAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG697405
EMBL· GenBank· DDBJ
EFQ35978.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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