E3QRY8 · GFA_COLGM

Function

function

Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site27Zn2+ 1 (UniProtKB | ChEBI); structural
Binding site29Zn2+ 1 (UniProtKB | ChEBI); structural
Binding site48Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site50Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site53Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site95Zn2+ 1 (UniProtKB | ChEBI); structural
Binding site98Zn2+ 1 (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Molecular FunctionS-(hydroxymethyl)glutathione synthase activity
Molecular Functionzinc ion binding
Biological Processformaldehyde catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative glutathione-dependent formaldehyde-activating enzyme
  • EC number
  • Alternative names
    • S-(hydroxymethyl)glutathione synthase

Gene names

    • ORF names
      GLRG_08555

Organism names

Accessions

  • Primary accession
    E3QRY8

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004061581-191Putative glutathione-dependent formaldehyde-activating enzyme

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-166CENP-V/GFA

Sequence similarities

Belongs to the Gfa family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    20,901
  • Last updated
    2011-01-11 v1
  • Checksum
    F0BC9194866BA9B4
MAPTLHPLIDNGITKGDPNFSGGTLRCHCRSKPVEVLLGGNVAHNHACGCSKCWKPAGSLFSVVGVIPREQVKVTANEEKLHIIDDSAVILRNACKECGVHMYGRIEKPHPFKGLDFVHVELSDQKGWQEPQFAAFVSSIIEQGFNPKGTDGVRRKFKSVGLETYDTLSPTLVDLISTWTAQQNGRLPAKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG697372
EMBL· GenBank· DDBJ
EFQ33626.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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