E3H2A8 · E3H2A8_ROTDC

Function

function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site118Proton donor
Binding site119Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site154Zn2+ 2 (UniProtKB | ChEBI)
Binding site184Zn2+ 2 (UniProtKB | ChEBI)
Binding site235Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site236dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site272Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site273-275dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site294-297dihydroxyacetone phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionfructose-bisphosphate aldolase activity
Molecular Functionzinc ion binding
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-bisphosphate aldolase
  • EC number
  • Short names
    FBP aldolase

Gene names

    • Name
      fbaA
    • Ordered locus names
      HMPREF0733_10798

Organism names

Accessions

  • Primary accession
    E3H2A8

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the class II fructose-bisphosphate aldolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    38,759
  • Last updated
    2011-01-11 v1
  • Checksum
    15EAE19F03036854
MAFRRANKTTGIYVFPHPSQGVSMAIATPEVYAEMLENAKAKGFAYPAVNVTSSQTLNAALRGFAEAGSDGIVQASTGGAAYWSGASKKDMVAGSLAFAAYAREIAKQYDVNIALHTDHCPKDKLDGFVLPLLAESEKAVARGEDPIFNSHMWDGSAIDLDENLKIAAELLERTNKAKIVLEVEIGAVGGEEDGVEGAIDDSLYTTVDDAVKTVEALGLGEKGRYIAALTFGNVHGVYKPGNVHLRPELLKQIQDEIGAKYGKEKPFSLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFTRPVAGHMFTNYDGVLKVDGEVGNKKAYDPRVWGAKAEEGMAARVVEACQQLGSAGTSLNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002280
EMBL· GenBank· DDBJ
ADP40256.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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