E3H2A8 · E3H2A8_ROTDC
- ProteinFructose-bisphosphate aldolase
- GenefbaA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids364 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Catalytic activity
- beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
Cofactor
Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 118 | Proton donor | |||
Binding site | 119 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 154 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 184 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 235 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 236 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | |||
Binding site | 272 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 273-275 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | |||
Binding site | 294-297 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | fructose-bisphosphate aldolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFructose-bisphosphate aldolase
- EC number
- Short namesFBP aldolase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Rothia
Accessions
- Primary accessionE3H2A8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length364
- Mass (Da)38,759
- Last updated2011-01-11 v1
- Checksum15EAE19F03036854
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002280 EMBL· GenBank· DDBJ | ADP40256.1 EMBL· GenBank· DDBJ | Genomic DNA |