E2QTD3 · TDRD5_CANLF
- ProteinTudor domain-containing protein 5
- GeneTDRD5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids985 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatoid body | |
Cellular Component | P granule | |
Cellular Component | pi-body | |
Biological Process | P granule organization | |
Biological Process | piRNA processing | |
Biological Process | retrotransposon silencing by piRNA-directed DNA methylation | |
Biological Process | spermatid development | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTudor domain-containing protein 5
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionE2QTD3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000408347 | 1-985 | Tudor domain-containing protein 5 | |||
Sequence: MSEQERVQECLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVTVSPCGDGTIILRAIPDESTKGIANLVAKQRSSHKVRNSMQKGRPSVCSGSSSRRRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQYVQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKRSISEEKQRGWPAVTKGGKMFTQPFRMKQQGSYSTGSPVAKACFSQPTSNMEPPKQILNAEKTFKSNVVETSRLNHTEKLNQLENTFKSVISQIGPGGTINPELKHKLRFVVSKFPEGLLISKLLREFEIMFKEQLSPKQLGFLNVTELVGALSDILRVEFREGEQDLLVFDANMKPLASVQSDKKIDVKACVSSPPRNSLSTAAVKETAWDCLPKNHREPEQKICKKPNLVVKPLQLQVGVNKSELNLAMANHDIPPDAVRDKKLCRLPPLDTSTLVGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYAMPEYFIQPGHLCCVRISEDKWWYRVIIHRVLGKQEVEVFYPDFGNIGTVQKSSLRFLKWCYTKLPAQAIPCSLAWVRPVEEHWTSRAIIQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENVPSKGFRELNPLALYTKSSAGPEDVVLTELGCPSQQHYFNEDREISPQSKENELPTLDEIPIGMPCLESVTIGDDVWDENWLPLQAKMGKGGDAPSHLFTSSRGGKKPYLSCKEMPQKDWCFSAPKDMWDDSWQPSSLVNGMKVEVQKQEELSAQEKNIGTTRSQKQPNLESSSDSPTLPKLEEFYISLVESQQSAEGSQFEPSSIQTQVKQMQLSTAALSTTPAAVDSPEKHSGSVESSPESLKNDFSSSHAITVFKDKSHGAMDQLSLILSPEHQISQKLYIPRSTATAALGAAARLATSRRLLHWYPSVKRMEA | ||||||
Modified residue | 897 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-80 | HTH OST-type 1 | ||||
Sequence: VQECLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVTVSPCGDGTIILRAIP | ||||||
Compositional bias | 98-117 | Polar residues | ||||
Sequence: HKVRNSMQKGRPSVCSGSSS | ||||||
Region | 98-119 | Disordered | ||||
Sequence: HKVRNSMQKGRPSVCSGSSSRR | ||||||
Domain | 127-202 | HTH OST-type 2 | ||||
Sequence: VPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQYVQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKRS | ||||||
Domain | 300-374 | HTH OST-type 3 | ||||
Sequence: INPELKHKLRFVVSKFPEGLLISKLLREFEIMFKEQLSPKQLGFLNVTELVGALSDILRVEFREGEQDLLVFDAN | ||||||
Domain | 530-589 | Tudor | ||||
Sequence: FIQPGHLCCVRISEDKWWYRVIIHRVLGKQEVEVFYPDFGNIGTVQKSSLRFLKWCYTKL | ||||||
Region | 818-846 | Disordered | ||||
Sequence: EELSAQEKNIGTTRSQKQPNLESSSDSPT | ||||||
Compositional bias | 821-846 | Polar residues | ||||
Sequence: SAQEKNIGTTRSQKQPNLESSSDSPT | ||||||
Region | 889-915 | Disordered | ||||
Sequence: STTPAAVDSPEKHSGSVESSPESLKND |
Sequence similarities
Belongs to the TDRD5 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length985
- Mass (Da)110,613
- Last updated2010-11-30 v1
- ChecksumEF623DA36DA53536
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 98-117 | Polar residues | ||||
Sequence: HKVRNSMQKGRPSVCSGSSS | ||||||
Compositional bias | 821-846 | Polar residues | ||||
Sequence: SAQEKNIGTTRSQKQPNLESSSDSPT |
Keywords
- Technical term