E2QTD3 · TDRD5_CANLF

Function

function

Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatoid body
Cellular ComponentP granule
Cellular Componentpi-body
Biological ProcessP granule organization
Biological ProcesspiRNA processing
Biological Processretrotransposon silencing by piRNA-directed DNA methylation
Biological Processspermatid development
Biological Processspermatogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tudor domain-containing protein 5

Gene names

    • Name
      TDRD5

Organism names

Accessions

  • Primary accession
    E2QTD3

Proteomes

Subcellular Location

Cytoplasm
Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004083471-985Tudor domain-containing protein 5
Modified residue897Phosphoserine

Keywords

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain7-80HTH OST-type 1
Compositional bias98-117Polar residues
Region98-119Disordered
Domain127-202HTH OST-type 2
Domain300-374HTH OST-type 3
Domain530-589Tudor
Region818-846Disordered
Compositional bias821-846Polar residues
Region889-915Disordered

Sequence similarities

Belongs to the TDRD5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    985
  • Mass (Da)
    110,613
  • Last updated
    2010-11-30 v1
  • Checksum
    EF623DA36DA53536
MSEQERVQECLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVTVSPCGDGTIILRAIPDESTKGIANLVAKQRSSHKVRNSMQKGRPSVCSGSSSRRRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQYVQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKRSISEEKQRGWPAVTKGGKMFTQPFRMKQQGSYSTGSPVAKACFSQPTSNMEPPKQILNAEKTFKSNVVETSRLNHTEKLNQLENTFKSVISQIGPGGTINPELKHKLRFVVSKFPEGLLISKLLREFEIMFKEQLSPKQLGFLNVTELVGALSDILRVEFREGEQDLLVFDANMKPLASVQSDKKIDVKACVSSPPRNSLSTAAVKETAWDCLPKNHREPEQKICKKPNLVVKPLQLQVGVNKSELNLAMANHDIPPDAVRDKKLCRLPPLDTSTLVGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYAMPEYFIQPGHLCCVRISEDKWWYRVIIHRVLGKQEVEVFYPDFGNIGTVQKSSLRFLKWCYTKLPAQAIPCSLAWVRPVEEHWTSRAIIQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENVPSKGFRELNPLALYTKSSAGPEDVVLTELGCPSQQHYFNEDREISPQSKENELPTLDEIPIGMPCLESVTIGDDVWDENWLPLQAKMGKGGDAPSHLFTSSRGGKKPYLSCKEMPQKDWCFSAPKDMWDDSWQPSSLVNGMKVEVQKQEELSAQEKNIGTTRSQKQPNLESSSDSPTLPKLEEFYISLVESQQSAEGSQFEPSSIQTQVKQMQLSTAALSTTPAAVDSPEKHSGSVESSPESLKNDFSSSHAITVFKDKSHGAMDQLSLILSPEHQISQKLYIPRSTATAALGAAARLATSRRLLHWYPSVKRMEA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias98-117Polar residues
Compositional bias821-846Polar residues

Keywords

Similar Proteins

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