E2QFS2 · E2QFS2_ECOLX

  • Protein
    Rhomboid protease GlpG
  • Gene
    glpG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Rhomboid-type serine protease that catalyzes intramembrane proteolysis.

Catalytic activity

  • Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
    EC:3.4.21.105 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

127620406080100120140160180200220240260
TypeIDPosition(s)Description
Active site201Nucleophile
Active site254

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rhomboid protease GlpG
  • EC number
  • Alternative names
    • Intramembrane serine protease

Gene names

    • Name
      glpG
    • ORF names
      A2J79_001565
      , A5U30_001347
      , ACU57_16750
      , B6R15_000487
      , BANRA_02054
      , BGM66_003747
      , BK383_20995
      , BMT91_03755
      , BTB68_000079
      , C0P57_000825
      , C2M16_11410
      , C719_002282
      , C9Z68_21530
      , CIG67_16405
      , CTR35_001905
      , D3C88_28800
      , D3G36_07055
      , D4N09_13190
      , D9E49_05745
      , DL968_00465
      , DTL43_14210
      , DU321_12520
      , E6D34_04420
      , EIZ93_01800
      , EWK56_15830
      , ExPECSC038_01129
      , F7F11_12270
      , F9461_03235
      , FGAF848_25000
      , FKO60_14155
      , FOI11_018650
      , FOI11_04530
      , FPI65_20960
      , FWK02_23410
      , G3V95_06200
      , G4A38_26785
      , G4A47_26480
      , GNW61_08665
      , GOP25_12675
      , GP944_08445
      , GP954_22660
      , GP965_26235
      , GP975_23100
      , GP979_17440
      , GQM13_20440
      , GQM21_28535
      , GRW05_23505
      , GRW24_24165
      , GTP92_12530
      , HEP34_002491
      , HI055_002272
      , HJQ60_002885
      , HLX92_09550
      , HVV39_09850
      , HVY77_01555
      , IFC14_001635
      , IH772_08605
      , J0541_002173
      , JNA68_03410
      , NCTC11126_02613
      , NCTC13148_03608
      , NCTC8500_00166
      , NCTC9044_01494
      , NCTC9045_00424
      , NCTC9073_00544
      , NCTC9075_00568
      , NCTC9117_00587
      , NCTC9702_00414
      , NCTC9706_02695
      , P6223_000248
      , PWL68_002748
      , QDW62_01585
      , QO046_14275
      , R8G00_13855
      , RZR61_07330
      , SAMEA3472056_02022
      , SAMEA3752557_02074

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 347
    • 570
    • 1409
    • 93335
    • 412057
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    E2QFS2
  • Secondary accessions
    • A0A236GUM1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane96-115Helical
Transmembrane135-160Helical
Transmembrane172-188Helical
Transmembrane194-212Helical
Transmembrane224-242Helical
Transmembrane248-267Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-82Peptidase S54 GlpG peptidase N-terminal
Domain133-268Peptidase S54 rhomboid

Sequence similarities

Belongs to the peptidase S54 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    276
  • Mass (Da)
    31,307
  • Last updated
    2010-11-30 v1
  • Checksum
    6F67374E609968FC
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAUZHL010000003
EMBL· GenBank· DDBJ
CAK1211067.1
EMBL· GenBank· DDBJ
Genomic DNA
AASATZ010000006
EMBL· GenBank· DDBJ
EFA4417626.1
EMBL· GenBank· DDBJ
Genomic DNA
AASFZR010000008
EMBL· GenBank· DDBJ
EFB4531626.1
EMBL· GenBank· DDBJ
Genomic DNA
AASHPR010000013
EMBL· GenBank· DDBJ
EFC3524779.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEBA010000006
EMBL· GenBank· DDBJ
EFC9748542.1
EMBL· GenBank· DDBJ
Genomic DNA
AASRHK010000001
EMBL· GenBank· DDBJ
EFF8952199.1
EMBL· GenBank· DDBJ
Genomic DNA
AASURL010000071
EMBL· GenBank· DDBJ
EFH0367260.1
EMBL· GenBank· DDBJ
Genomic DNA
AASVQO010000002
EMBL· GenBank· DDBJ
EFH3672237.1
EMBL· GenBank· DDBJ
Genomic DNA
AASWIS010000012
EMBL· GenBank· DDBJ
EFH5893088.1
EMBL· GenBank· DDBJ
Genomic DNA
AASWOY010000015
EMBL· GenBank· DDBJ
EFH6648816.1
EMBL· GenBank· DDBJ
Genomic DNA
AATCLQ010000007
EMBL· GenBank· DDBJ
EFJ6481226.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJOC010000007
EMBL· GenBank· DDBJ
EFM0253097.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJYL010000020
EMBL· GenBank· DDBJ
EFM1446161.1
EMBL· GenBank· DDBJ
Genomic DNA
AATLXB010000003
EMBL· GenBank· DDBJ
EFM7859291.1
EMBL· GenBank· DDBJ
Genomic DNA
AATLZG010000007
EMBL· GenBank· DDBJ
EFM8153759.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVTXU010000001
EMBL· GenBank· DDBJ
EGE1986150.1
EMBL· GenBank· DDBJ
Genomic DNA
AAXDPX010000010
EMBL· GenBank· DDBJ
EGO6679140.1
EMBL· GenBank· DDBJ
Genomic DNA
ABLFQU030000002
EMBL· GenBank· DDBJ
EMM0023759.1
EMBL· GenBank· DDBJ
Genomic DNA
ABKSHZ030000007
EMBL· GenBank· DDBJ
EMM9722613.1
EMBL· GenBank· DDBJ
Genomic DNA
BFIH01000031
EMBL· GenBank· DDBJ
GCO18999.1
EMBL· GenBank· DDBJ
Genomic DNA
DABDSA010000011
EMBL· GenBank· DDBJ
HAI2141946.1
EMBL· GenBank· DDBJ
Genomic DNA
DABERK010000015
EMBL· GenBank· DDBJ
HAI5332889.1
EMBL· GenBank· DDBJ
Genomic DNA
DABUHV010000006
EMBL· GenBank· DDBJ
HAN4353205.1
EMBL· GenBank· DDBJ
Genomic DNA
DADUEU010000011
EMBL· GenBank· DDBJ
HBB1573270.1
EMBL· GenBank· DDBJ
Genomic DNA
VZEL01000010
EMBL· GenBank· DDBJ
KAB0124343.1
EMBL· GenBank· DDBJ
Genomic DNA
LDYI01000115
EMBL· GenBank· DDBJ
KPO09670.1
EMBL· GenBank· DDBJ
Genomic DNA
JABFNF010000006
EMBL· GenBank· DDBJ
MBA1886417.1
EMBL· GenBank· DDBJ
Genomic DNA
JACGTG010000001
EMBL· GenBank· DDBJ
MBA6239298.1
EMBL· GenBank· DDBJ
Genomic DNA
JACZOI010000018
EMBL· GenBank· DDBJ
MBE0977363.1
EMBL· GenBank· DDBJ
Genomic DNA
JAETYU010000003
EMBL· GenBank· DDBJ
MBL6202251.1
EMBL· GenBank· DDBJ
Genomic DNA
JASMQD010000001
EMBL· GenBank· DDBJ
MDK2695532.1
EMBL· GenBank· DDBJ
Genomic DNA
JAWIHY010000009
EMBL· GenBank· DDBJ
MDV1987254.1
EMBL· GenBank· DDBJ
Genomic DNA
JAWPMK010000001
EMBL· GenBank· DDBJ
MDW9350668.1
EMBL· GenBank· DDBJ
Genomic DNA
ROAL01000004
EMBL· GenBank· DDBJ
MIB59923.1
EMBL· GenBank· DDBJ
Genomic DNA
RYCF01000003
EMBL· GenBank· DDBJ
MQK23060.1
EMBL· GenBank· DDBJ
Genomic DNA
WTML01000373
EMBL· GenBank· DDBJ
MWL01018.1
EMBL· GenBank· DDBJ
Genomic DNA
WTMQ01000008
EMBL· GenBank· DDBJ
MWL05787.1
EMBL· GenBank· DDBJ
Genomic DNA
WTQT01000803
EMBL· GenBank· DDBJ
MWR40887.1
EMBL· GenBank· DDBJ
Genomic DNA
WTQQ01000307
EMBL· GenBank· DDBJ
MWR90061.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRC01000792
EMBL· GenBank· DDBJ
MWT24378.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRN01001166
EMBL· GenBank· DDBJ
MWT87905.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRX01000009
EMBL· GenBank· DDBJ
MWU30815.1
EMBL· GenBank· DDBJ
Genomic DNA
WUIY01000278
EMBL· GenBank· DDBJ
MXI77162.1
EMBL· GenBank· DDBJ
Genomic DNA
WUIG01000839
EMBL· GenBank· DDBJ
MXJ11515.1
EMBL· GenBank· DDBJ
Genomic DNA
VLTB01000333
EMBL· GenBank· DDBJ
NDR93688.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGYI010000007
EMBL· GenBank· DDBJ
NEM85100.1
EMBL· GenBank· DDBJ
Genomic DNA
JABUPU010000091
EMBL· GenBank· DDBJ
NYP88610.1
EMBL· GenBank· DDBJ
Genomic DNA
JABUPJ010000093
EMBL· GenBank· DDBJ
NYQ42041.1
EMBL· GenBank· DDBJ
Genomic DNA
MOKI01000044
EMBL· GenBank· DDBJ
OJR52988.1
EMBL· GenBank· DDBJ
Genomic DNA
MPAF01000004
EMBL· GenBank· DDBJ
OOK31019.1
EMBL· GenBank· DDBJ
Genomic DNA
PPHQ01000008
EMBL· GenBank· DDBJ
PNY67627.1
EMBL· GenBank· DDBJ
Genomic DNA
CP057293
EMBL· GenBank· DDBJ
QMF65823.1
EMBL· GenBank· DDBJ
Genomic DNA
CP055981
EMBL· GenBank· DDBJ
QMS38306.1
EMBL· GenBank· DDBJ
Genomic DNA
CP063369
EMBL· GenBank· DDBJ
QOY30408.1
EMBL· GenBank· DDBJ
Genomic DNA
QOGZ01000014
EMBL· GenBank· DDBJ
RDA38086.1
EMBL· GenBank· DDBJ
Genomic DNA
QXHA01001760
EMBL· GenBank· DDBJ
RIB38513.1
EMBL· GenBank· DDBJ
Genomic DNA
RRVG01000012
EMBL· GenBank· DDBJ
RRL47296.1
EMBL· GenBank· DDBJ
Genomic DNA
NPIM01000144
EMBL· GenBank· DDBJ
RVE11496.1
EMBL· GenBank· DDBJ
Genomic DNA
SERV01000010
EMBL· GenBank· DDBJ
RYL81119.1
EMBL· GenBank· DDBJ
Genomic DNA
UARS01000006
EMBL· GenBank· DDBJ
SPW45349.1
EMBL· GenBank· DDBJ
Genomic DNA
UASD01000004
EMBL· GenBank· DDBJ
SPX09297.1
EMBL· GenBank· DDBJ
Genomic DNA
UCVA01000006
EMBL· GenBank· DDBJ
SQK83893.1
EMBL· GenBank· DDBJ
Genomic DNA
UCZA01000010
EMBL· GenBank· DDBJ
SQP81858.1
EMBL· GenBank· DDBJ
Genomic DNA
UGDD01000002
EMBL· GenBank· DDBJ
STJ52622.1
EMBL· GenBank· DDBJ
Genomic DNA
UGDC01000003
EMBL· GenBank· DDBJ
STJ78067.1
EMBL· GenBank· DDBJ
Genomic DNA
UGET01000004
EMBL· GenBank· DDBJ
STL85316.1
EMBL· GenBank· DDBJ
Genomic DNA
UGFG01000001
EMBL· GenBank· DDBJ
STM36472.1
EMBL· GenBank· DDBJ
Genomic DNA
UGGJ01000004
EMBL· GenBank· DDBJ
STN85608.1
EMBL· GenBank· DDBJ
Genomic DNA
UGEM01000004
EMBL· GenBank· DDBJ
STP17159.1
EMBL· GenBank· DDBJ
Genomic DNA
RRGJ01000044
EMBL· GenBank· DDBJ
TJQ09460.1
EMBL· GenBank· DDBJ
Genomic DNA
VSBS01001050
EMBL· GenBank· DDBJ
TXS99313.1
EMBL· GenBank· DDBJ
Genomic DNA
QYOH01000011
EMBL· GenBank· DDBJ
TXU35567.1
EMBL· GenBank· DDBJ
Genomic DNA
VHKY01000009
EMBL· GenBank· DDBJ
TZE48015.1
EMBL· GenBank· DDBJ
Genomic DNA
UWVU01000001
EMBL· GenBank· DDBJ
VCW53196.1
EMBL· GenBank· DDBJ
Genomic DNA
LR134238
EMBL· GenBank· DDBJ
VED08758.1
EMBL· GenBank· DDBJ
Genomic DNA
LR134246
EMBL· GenBank· DDBJ
VED32715.1
EMBL· GenBank· DDBJ
Genomic DNA
CP122634
EMBL· GenBank· DDBJ
WHI02297.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp