E2QFS2 · E2QFS2_ECOLX
- ProteinRhomboid protease GlpG
- GeneglpG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids276 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 201 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 254 | |||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRhomboid protease GlpG
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionE2QFS2
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 96-115 | Helical | ||||
Sequence: VTWVMMIACVVVFIAMQILG | ||||||
Transmembrane | 135-160 | Helical | ||||
Sequence: FWRYFTHALMHFSLMHILFNLLWWWY | ||||||
Transmembrane | 172-188 | Helical | ||||
Sequence: GKLIVITLISALLSGYV | ||||||
Transmembrane | 194-212 | Helical | ||||
Sequence: GPWFGGLSGVVYALMGYVW | ||||||
Transmembrane | 224-242 | Helical | ||||
Sequence: YLQRGLIIFALIWIVAGWF | ||||||
Transmembrane | 248-267 | Helical | ||||
Sequence: SMANGAHIAGLAVGLAMAFV |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-82 | Peptidase S54 GlpG peptidase N-terminal | ||||
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRR | ||||||
Domain | 133-268 | Peptidase S54 rhomboid | ||||
Sequence: FEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVD |
Sequence similarities
Belongs to the peptidase S54 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length276
- Mass (Da)31,307
- Last updated2010-11-30 v1
- Checksum6F67374E609968FC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAUZHL010000003 EMBL· GenBank· DDBJ | CAK1211067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASATZ010000006 EMBL· GenBank· DDBJ | EFA4417626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASFZR010000008 EMBL· GenBank· DDBJ | EFB4531626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASHPR010000013 EMBL· GenBank· DDBJ | EFC3524779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEBA010000006 EMBL· GenBank· DDBJ | EFC9748542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASRHK010000001 EMBL· GenBank· DDBJ | EFF8952199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASURL010000071 EMBL· GenBank· DDBJ | EFH0367260.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASVQO010000002 EMBL· GenBank· DDBJ | EFH3672237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWIS010000012 EMBL· GenBank· DDBJ | EFH5893088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWOY010000015 EMBL· GenBank· DDBJ | EFH6648816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATCLQ010000007 EMBL· GenBank· DDBJ | EFJ6481226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJOC010000007 EMBL· GenBank· DDBJ | EFM0253097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJYL010000020 EMBL· GenBank· DDBJ | EFM1446161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATLXB010000003 EMBL· GenBank· DDBJ | EFM7859291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATLZG010000007 EMBL· GenBank· DDBJ | EFM8153759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVTXU010000001 EMBL· GenBank· DDBJ | EGE1986150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAXDPX010000010 EMBL· GenBank· DDBJ | EGO6679140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000002 EMBL· GenBank· DDBJ | EMM0023759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABKSHZ030000007 EMBL· GenBank· DDBJ | EMM9722613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BFIH01000031 EMBL· GenBank· DDBJ | GCO18999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABDSA010000011 EMBL· GenBank· DDBJ | HAI2141946.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABERK010000015 EMBL· GenBank· DDBJ | HAI5332889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABUHV010000006 EMBL· GenBank· DDBJ | HAN4353205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000011 EMBL· GenBank· DDBJ | HBB1573270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VZEL01000010 EMBL· GenBank· DDBJ | KAB0124343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LDYI01000115 EMBL· GenBank· DDBJ | KPO09670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABFNF010000006 EMBL· GenBank· DDBJ | MBA1886417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACGTG010000001 EMBL· GenBank· DDBJ | MBA6239298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZOI010000018 EMBL· GenBank· DDBJ | MBE0977363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAETYU010000003 EMBL· GenBank· DDBJ | MBL6202251.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JASMQD010000001 EMBL· GenBank· DDBJ | MDK2695532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWIHY010000009 EMBL· GenBank· DDBJ | MDV1987254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWPMK010000001 EMBL· GenBank· DDBJ | MDW9350668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ROAL01000004 EMBL· GenBank· DDBJ | MIB59923.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RYCF01000003 EMBL· GenBank· DDBJ | MQK23060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTML01000373 EMBL· GenBank· DDBJ | MWL01018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTMQ01000008 EMBL· GenBank· DDBJ | MWL05787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTQT01000803 EMBL· GenBank· DDBJ | MWR40887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTQQ01000307 EMBL· GenBank· DDBJ | MWR90061.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRC01000792 EMBL· GenBank· DDBJ | MWT24378.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRN01001166 EMBL· GenBank· DDBJ | MWT87905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRX01000009 EMBL· GenBank· DDBJ | MWU30815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUIY01000278 EMBL· GenBank· DDBJ | MXI77162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUIG01000839 EMBL· GenBank· DDBJ | MXJ11515.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VLTB01000333 EMBL· GenBank· DDBJ | NDR93688.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYI010000007 EMBL· GenBank· DDBJ | NEM85100.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABUPU010000091 EMBL· GenBank· DDBJ | NYP88610.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABUPJ010000093 EMBL· GenBank· DDBJ | NYQ42041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MOKI01000044 EMBL· GenBank· DDBJ | OJR52988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPAF01000004 EMBL· GenBank· DDBJ | OOK31019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PPHQ01000008 EMBL· GenBank· DDBJ | PNY67627.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP057293 EMBL· GenBank· DDBJ | QMF65823.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP055981 EMBL· GenBank· DDBJ | QMS38306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063369 EMBL· GenBank· DDBJ | QOY30408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOGZ01000014 EMBL· GenBank· DDBJ | RDA38086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QXHA01001760 EMBL· GenBank· DDBJ | RIB38513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RRVG01000012 EMBL· GenBank· DDBJ | RRL47296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NPIM01000144 EMBL· GenBank· DDBJ | RVE11496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SERV01000010 EMBL· GenBank· DDBJ | RYL81119.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UARS01000006 EMBL· GenBank· DDBJ | SPW45349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UASD01000004 EMBL· GenBank· DDBJ | SPX09297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UCVA01000006 EMBL· GenBank· DDBJ | SQK83893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UCZA01000010 EMBL· GenBank· DDBJ | SQP81858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDD01000002 EMBL· GenBank· DDBJ | STJ52622.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDC01000003 EMBL· GenBank· DDBJ | STJ78067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGET01000004 EMBL· GenBank· DDBJ | STL85316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGFG01000001 EMBL· GenBank· DDBJ | STM36472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGGJ01000004 EMBL· GenBank· DDBJ | STN85608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGEM01000004 EMBL· GenBank· DDBJ | STP17159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RRGJ01000044 EMBL· GenBank· DDBJ | TJQ09460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VSBS01001050 EMBL· GenBank· DDBJ | TXS99313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QYOH01000011 EMBL· GenBank· DDBJ | TXU35567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHKY01000009 EMBL· GenBank· DDBJ | TZE48015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVU01000001 EMBL· GenBank· DDBJ | VCW53196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR134238 EMBL· GenBank· DDBJ | VED08758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR134246 EMBL· GenBank· DDBJ | VED32715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP122634 EMBL· GenBank· DDBJ | WHI02297.1 EMBL· GenBank· DDBJ | Genomic DNA |