E2QDB5 · E2QDB5_PHACH

Function

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site154FAD (UniProtKB | ChEBI)
Binding site156FAD (UniProtKB | ChEBI)
Binding site171FAD (UniProtKB | ChEBI)
Binding site173FAD (UniProtKB | ChEBI)
Binding site180FAD (UniProtKB | ChEBI)
Binding site181FAD (UniProtKB | ChEBI)
Binding site222FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Function2-(3-amino-3-carboxypropyl)histidine synthase activity
Molecular Functioncytochrome-b5 reductase activity, acting on NAD(P)H
Molecular FunctionNADH dehydrogenase activity
Biological Processprotein histidyl modification to diphthamide
Biological ProcesstRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-cytochrome b5 reductase
  • EC number

Organism names

Accessions

  • Primary accession
    E2QDB5

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane70-89Helical

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain102-205FAD-binding FR-type

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    35,520
  • Last updated
    2010-11-30 v1
  • Checksum
    BFBB4F9CD09BE151
MPNRYQLAFIASFLGVFSGLVLVSNFVKTKLKAAGYDPAQLILIGLPKSEDNRSPPPSPLPAWLSPHSAMFAQLLALILAALTSAAIYYKFGAKRKPVLDPGKWQEFPLKEKIVISPNTAIYRFALPHPQDVLGLPIGQHISVQAEINGKDIMRSYTPTSSDDDLGHFDLLIKAYEKGNISRYISLLKIGDKIRVKGPKGQFNYSPTLSRHLGMIAGGTGITPMLQIIRAALKNPADKTKLSLIYANVNYEDILLKKELDLLAQNHPDRFTVYYVLNNPPENWNGGVGFVTKEQIQEHMPPSSDDIKILMCGPPPMMNAMK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY835609
EMBL· GenBank· DDBJ
AAX49402.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp