E2Q767 · E2Q767_STRCL
- ProteinGlucosamine-6-phosphate deaminase
- GenenagB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids294 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Catalytic activity
- alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4+
Activity regulation
Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
Pathway
Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 101 | Proton acceptor; for enolization step | |||
Active site | 170 | For ring-opening step | |||
Active site | 172 | Proton acceptor; for ring-opening step | |||
Active site | 177 | For ring-opening step | |||
Site | 180 | Part of the allosteric site | |||
Site | 187 | Part of the allosteric site | |||
Site | 189 | Part of the allosteric site | |||
Site | 190 | Part of the allosteric site | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glucosamine-6-phosphate deaminase activity | |
Molecular Function | identical protein binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | glucosamine catabolic process | |
Biological Process | N-acetylglucosamine catabolic process | |
Biological Process | N-acetylneuraminate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucosamine-6-phosphate deaminase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionE2Q767
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 44-263 | Glucosamine/galactosamine-6-phosphate isomerase | |||
Sequence similarities
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length294
- Mass (Da)30,737
- Last updated2010-11-30 v1
- ChecksumEEB7E33200734444
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM000913 EMBL· GenBank· DDBJ | EFG05314.1 EMBL· GenBank· DDBJ | Genomic DNA |