E2LWQ3 · E2LWQ3_MONPE
- ProteinUDP-glucose 6-dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate
Pathway
Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 54 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 85-88 | substrate | ||||
Sequence: FLAE | ||||||
Binding site | 88 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 143 | substrate | ||||
Sequence: K | ||||||
Binding site | 188-192 | substrate | ||||
Sequence: FLKAS | ||||||
Binding site | 196 | substrate | ||||
Sequence: G | ||||||
Active site | 199 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 202 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 262 | substrate | ||||
Sequence: K | ||||||
Binding site | 269 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NAD binding | |
Molecular Function | UDP-glucose 6-dehydrogenase activity | |
Biological Process | polysaccharide biosynthetic process | |
Biological Process | UDP-glucuronate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucose 6-dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Marasmiineae > Marasmiaceae > Moniliophthora
Accessions
- Primary accessionE2LWQ3
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 255-371 | UDP-glucose/GDP-mannose dehydrogenase C-terminal | ||||
Sequence: AVLGFAFKADTGDTRESAAITLIKDFQNERALVNIYDPQVPHDQIWTDLSEASPHLPLETIRKQVTICGSALEACKNAEAVVISTEWKEFKAIDWEMVYQNMNKPAFVFDGRLLVDA |
Sequence similarities
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length380
- Mass (Da)41,957
- Last updated2010-11-30 v1
- Checksum0D571A13D99D787F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 380 | |||||
Sequence: K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ABRE01016750 EMBL· GenBank· DDBJ | EEB90148.1 EMBL· GenBank· DDBJ | Genomic DNA |