E2JDR2 · E2JDR2_MESAU
- ProteinOccludin
- GeneOCLN
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids523 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | bicellular tight junction | |
Cellular Component | cytoplasmic vesicle | |
Biological Process | bicellular tight junction assembly |
Names & Taxonomy
Protein names
- Recommended nameOccludin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus
Accessions
- Primary accessionE2JDR2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 64-89 | Helical | ||||
Sequence: VIRILSMLIIVMCIAIFACVASTLAW | ||||||
Transmembrane | 101-120 | Helical | ||||
Sequence: SLGYPYAGSGFGSFGSSYGY | ||||||
Transmembrane | 140-161 | Helical | ||||
Sequence: FLLAMAAFCFIASLVIFVTSVI | ||||||
Transmembrane | 173-195 | Helical | ||||
Sequence: LIVIIVSAILGILVFIATIVYIM | ||||||
Transmembrane | 244-265 | Helical | ||||
Sequence: AIAIVLGFMIIVAFALIIFFAV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 216↔237 | |||||
Sequence: CNQFYTPGATGLYVDQYLYHYC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 60-269 | MARVEL | ||||
Sequence: SPPGVIRILSMLIIVMCIAIFACVASTLAWDRAYGTGIFGGSLGYPYAGSGFGSFGSSYGYGYGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGILVFIATIVYIMGVNPTAQASGSMYGSQIYAMCNQFYTPGATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRR | ||||||
Region | 302-339 | Disordered | ||||
Sequence: SAGTQDMPPPPSEYAERVDSPMAYSSNGKVDGKRSYPE | ||||||
Region | 356-408 | Disordered | ||||
Sequence: PLTSPVDDFRQPRYSSSGNLETPSKRAPTKGRAGKLKRAEPDHYETDYTTGGE | ||||||
Compositional bias | 364-379 | Polar residues | ||||
Sequence: FRQPRYSSSGNLETPS | ||||||
Compositional bias | 388-405 | Basic and acidic residues | ||||
Sequence: AGKLKRAEPDHYETDYTT | ||||||
Domain | 415-523 | OCEL | ||||
Sequence: EDWVREYPPITSDQQRQLYKRDFDTGLQEYKSLQAELDEVSKELSRLDKELDDYREESEEYMAAADEYNRLKQVKRSADYKSKRNYCKQLKSKLSHIKRMVGDYDKRKT | ||||||
Coiled coil | 437-488 | |||||
Sequence: FDTGLQEYKSLQAELDEVSKELSRLDKELDDYREESEEYMAAADEYNRLKQV |
Sequence similarities
Belongs to the ELL/occludin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length523
- Mass (Da)59,246
- Last updated2010-11-30 v1
- ChecksumD14AF54B3448F9BE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 364-379 | Polar residues | ||||
Sequence: FRQPRYSSSGNLETPS | ||||||
Compositional bias | 388-405 | Basic and acidic residues | ||||
Sequence: AGKLKRAEPDHYETDYTT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HQ174780 EMBL· GenBank· DDBJ | ADN52076.1 EMBL· GenBank· DDBJ | mRNA |