E2JDR2 · E2JDR2_MESAU

Function

function

May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbicellular tight junction
Cellular Componentcytoplasmic vesicle
Biological Processbicellular tight junction assembly

Names & Taxonomy

Protein names

  • Recommended name
    Occludin

Gene names

    • Name
      OCLN
    • Synonyms
      Ocln

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus

Accessions

  • Primary accession
    E2JDR2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cell junction, tight junction
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane64-89Helical
Transmembrane101-120Helical
Transmembrane140-161Helical
Transmembrane173-195Helical
Transmembrane244-265Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond216↔237

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain60-269MARVEL
Region302-339Disordered
Region356-408Disordered
Compositional bias364-379Polar residues
Compositional bias388-405Basic and acidic residues
Domain415-523OCEL
Coiled coil437-488

Sequence similarities

Belongs to the ELL/occludin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    523
  • Mass (Da)
    59,246
  • Last updated
    2010-11-30 v1
  • Checksum
    D14AF54B3448F9BE
MSVRPFESPPPYRPDEFKPNHYAPSNDVYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRAYGTGIFGGSLGYPYAGSGFGSFGSSYGYGYGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGILVFIATIVYIMGVNPTAQASGSMYGSQIYAMCNQFYTPGATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHTYDEQPPNVEEWVKNVSAGTQDMPPPPSEYAERVDSPMAYSSNGKVDGKRSYPESVYKSTPLVPEVAQELPLTSPVDDFRQPRYSSSGNLETPSKRAPTKGRAGKLKRAEPDHYETDYTTGGESCDELEEDWVREYPPITSDQQRQLYKRDFDTGLQEYKSLQAELDEVSKELSRLDKELDDYREESEEYMAAADEYNRLKQVKRSADYKSKRNYCKQLKSKLSHIKRMVGDYDKRKT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias364-379Polar residues
Compositional bias388-405Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ174780
EMBL· GenBank· DDBJ
ADN52076.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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