E2F6L1 · E2F6L1_PANTR
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionE2F6L1
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 84-105 | Helical | |||
Transmembrane | 117-134 | Helical | |||
Transmembrane | 140-160 | Helical | |||
Transmembrane | 172-191 | Helical | |||
Transmembrane | 211-233 | Helical | |||
Transmembrane | 245-266 | Helical | |||
Transmembrane | 272-294 | Helical | |||
Transmembrane | 301-319 | Helical | |||
Transmembrane | 325-347 | Helical | |||
Transmembrane | 368-386 | Helical | |||
Transmembrane | 406-428 | Helical | |||
Transmembrane | 584-602 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5008413584 | 22-603 | NADH-ubiquinone oxidoreductase chain 5 | ||
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 68-118 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | |||
Domain | 134-419 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | |||
Domain | 422-602 | NADH dehydrogenase subunit 5 C-terminal | |||
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)67,256
- Last updated2010-11-30 v1
- MD5 Checksum2A79D6F211BD4A063CF2B9A6997BC86A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM068573 EMBL· GenBank· DDBJ | ADF87997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN191216 EMBL· GenBank· DDBJ | AEO20794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN191224 EMBL· GenBank· DDBJ | AEO20898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX211959 EMBL· GenBank· DDBJ | ANP95882.1 EMBL· GenBank· DDBJ | Genomic DNA |