E1ZY18 · E1ZY18_CAMFO
- ProteinGlucose-6-phosphate 1-dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids758 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + H+ + NADPHThis reaction proceeds in the forward direction.
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Formicoidea > Formicidae > Formicinae > Camponotus
Accessions
- Primary accessionE1ZY18
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 149-169 | Helical | ||||
Sequence: VTLFSILSLNIVIERILVQYY | ||||||
Transmembrane | 189-209 | Helical | ||||
Sequence: LYRNIALILCAITLICTYYYY |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 280-455 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: VTLGASGDLAKKKIYPTLWWLFRDNLLPKPTTFIGYARSKLTVQQLREKCHPYMKVKSSEEEKYEEFWKLNHYVAGVYDKRDDFERLDRELQKYEQGQVAHRLFYLALPPSVFESVTLRLRLTCMGNKGWTRIIIEKPFGHDAISSQKLSENLASLFSEEQIYRIDHYLGKEMVQN | ||||||
Domain | 457-749 | Glucose-6-phosphate dehydrogenase C-terminal | ||||
Sequence: MTLRFGNRVFNPSWNRDNIASVQITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPASCHPDDIRNEKVKVLRCIKELQLENVILGQYVGDPDAEDPEAHLGYLDDPTVPTSSNTPTFALAVLKINNERWDGVPFILRCGKALNERKAEVRIQYHDVPGDIFDGKPKRNEMVIRVQPGEALYIKMMTKSPGITFDMEETELDLTYGNRYKDLKLPDAYERLILDVFCGSQMHFVRNDELQEAWRIFTPLLHRIEKEKIQPVPYKYGSRGPKEADDMAKRNNFAY |
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length758
- Mass (Da)88,451
- Last updated2010-11-30 v1
- Checksum26AB9AF1435BF281
Keywords
- Technical term