E1ZVX4 · E1ZVX4_CAMFO

Function

function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site264-271ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentspindle pole
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule severing ATPase activity
Biological Processcell division
Biological Processmicrotubule severing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1
    • ORF names
      EAG_07717

Organism names

  • Taxonomic identifier
  • Strain
    • C129
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Formicoidea > Formicidae > Formicinae > Camponotus

Accessions

  • Primary accession
    E1ZVX4

Proteomes

Subcellular Location

Cytoplasm
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Keywords

Interaction

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region104-198Disordered
Compositional bias132-153Polar residues
Compositional bias154-198Basic and acidic residues
Domain256-396AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    504
  • Mass (Da)
    57,452
  • Last updated
    2010-11-30 v1
  • Checksum
    959C21DF4B8394F6
MAVSINEICENTKLAREMALMGNYDTSGVYYQGVVQQIHRLLATIADATRKAKWQVVQHQIVQEFEEVKATSNTLQLFKVDTHAERLLGTSCLSFEEPTRDPALWSYGNSEPSWNQTPARDPDVWPPLTPAEQKNLKQQKVQQKQQNRTNARKSIATKKPDSKPSTKKDDKKIVKKDDTNKDKSETEKDVELEERKFEPSTTDKDLVEILERDIVQKNPNIHWDDIADLHEAKRLLEEAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGISSNSEDPSKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPNHEGREALLRINLREVKVDSSVNLTDIARKLKGYSGADITNVCRDASMMLMRKKIAGLRPDQIRQLPKEELDLPVSAADFDEAVERCNKSVSQEDLEKYEKWMSEFGSS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias132-153Polar residues
Compositional bias154-198Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL434663
EMBL· GenBank· DDBJ
EFN74666.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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