E1C3S7 · TDRD7_CHICK
- ProteinTudor domain-containing protein 7
- GeneTDRD7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1071 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | P granule | |
Cellular Component | ribonucleoprotein granule | |
Molecular Function | mRNA binding | |
Biological Process | lens fiber cell differentiation | |
Biological Process | lens morphogenesis in camera-type eye | |
Biological Process | P granule organization | |
Biological Process | piRNA processing | |
Biological Process | post-transcriptional regulation of gene expression | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTudor domain-containing protein 7
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionE1C3S7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to cytoplasmic RNA granules.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000409517 | 1-1071 | Tudor domain-containing protein 7 | |||
Sequence: MQEPDLVAKALRSVLHSSKHGIPLSELQDEYRSLTGEWIPFRHLGYATLEAYVASIPEVVRIERNQTGEVTCHAVACPETIYVRVWAVAHKRTSPIFLLFCCRQNIEKTLQMIRVLDICAIFKDPRWSSEVSFVVSVSVCLRRDQLSHHGFKRSCTFTCPEGLPLIQMVSFPIKSILSEKGLIPAYEKNHSNSEFYFSLTDNLNASGVETHTVASGRSVPNISEIQNRIKEILSKYRNGVWLSKIAQVYEETYREELSTTVLRQLEHWPHVCTVEKVRTGDQTYRILYPSKRIPPAVKSNTEQDQASQNVTSSKAGPVLKTSREAESASCSSDFKQNVVNILVKYPCGLWADALPKLYQDAYQRKFPEGILNNLQLLSDVCVVDYVSNVPQKAILYVKTQSCTDENLNVTEKVQIPDGAKATAEQQHEESKEQYPESISSVPPLVIPSEGPVSVLVIDVNNPNELIIRYVGKDYSGAQEQMEDKMKAYYSKNSTASQITFPSVGQLVAVHTEEEAWLRAQIISVEDKRLKLSCFCTYFGCITFRMCKPKENTHCCMKQCTSHKCKLTGLEVFSDDPLLLKAVELQAYHKICAVEILERSDIPVFVLYDTSGEDDININATCLKALYDKSFELNLQVDTLYTNVRVTSILSDGNMYCQLPSEGLSKLSEVLQKIEYYLLHQETSEFNVSQPYCGKICLFLCKGKWTRVEITIIHSRRALGVRFIDTGRVAYVKVTDLREIPSQFLREVIKIPPQAIKCCLADLPPDTGMWTPEAVLWLRDNVMDYAEFSMQVSVMEKRCVLKFWKAFIPISYLLADRSINRRINAVLWKHQKDVFLSVTSQGLAPPKHLNQGRLEKSDSLEPAVESRGVESATDVPPPLPLSEVGGFMDVYVSVACHPGHFIVQPWKEIHNLEALMEEMILYYSMAEERPVNIGTNKLYAAKIENRWYRVIVKGILRKGFLSVYVLDYGKHEVISIDKVQPLLDKFRKLPFQAIKAELAGVKSQQWSEEASIIFRNRVEKKPLVAQIQAINESTNSWDRKVVTYLVDTSIPDTDVWIHDFVCQSLAELSEAD |
Expression
Tissue specificity
Highly expressed in the developing lens.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-76 | HTH OST-type 1 | ||||
Sequence: EPDLVAKALRSVLHSSKHGIPLSELQDEYRSLTGEWIPFRHLGYATLEAYVASIPEVVRIERNQTGEVTCHAVA | ||||||
Domain | 221-289 | HTH OST-type 2 | ||||
Sequence: NISEIQNRIKEILSKYRNGVWLSKIAQVYEETYREELSTTVLRQLEHWPHVCTVEKVRTGDQTYRILYP | ||||||
Region | 295-318 | Disordered | ||||
Sequence: PAVKSNTEQDQASQNVTSSKAGPV | ||||||
Compositional bias | 296-318 | Polar residues | ||||
Sequence: AVKSNTEQDQASQNVTSSKAGPV | ||||||
Domain | 330-399 | HTH OST-type 3 | ||||
Sequence: CSSDFKQNVVNILVKYPCGLWADALPKLYQDAYQRKFPEGILNNLQLLSDVCVVDYVSNVPQKAILYVKT | ||||||
Domain | 500-557 | Tudor 1 | ||||
Sequence: FPSVGQLVAVHTEEEAWLRAQIISVEDKRLKLSCFCTYFGCITFRMCKPKENTHCCMK | ||||||
Domain | 689-746 | Tudor 2 | ||||
Sequence: QPYCGKICLFLCKGKWTRVEITIIHSRRALGVRFIDTGRVAYVKVTDLREIPSQFLRE |
Sequence similarities
Belongs to the TDRD7 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,071
- Mass (Da)121,561
- Last updated2010-11-02 v1
- Checksum34F25C0F8292717B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 296-318 | Polar residues | ||||
Sequence: AVKSNTEQDQASQNVTSSKAGPV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AADN02060121 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060122 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060123 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060124 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060125 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060126 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060127 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060128 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060129 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060130 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060131 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060132 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02060133 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |