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E1BMS3 · E1BMS3_BOVIN

  • Protein
    NAD(P)H oxidase (H2O2-forming)
  • Gene
    DUOX2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Catalytic activity

Pathway

Hormone biosynthesis; thyroid hormone biosynthesis.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular ComponentNADPH oxidase complex
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionheme binding
Molecular FunctionNAD(P)H oxidase H2O2-forming activity
Molecular Functionperoxidase activity
Molecular Functionsuperoxide-generating NAD(P)H oxidase activity
Biological Processadenohypophysis morphogenesis
Biological Processbone mineralization
Biological Processdefense response
Biological Processfertilization
Biological Processhormone biosynthetic process
Biological Processinner ear development
Biological Processmulticellular organism growth
Biological Processorganic acid metabolic process
Biological Processresponse to oxidative stress
Biological Processsuperoxide anion generation
Biological Processthyroid gland development
Biological Processthyroid hormone generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H oxidase (H2O2-forming)
  • EC number

Gene names

    • Name
      DUOX2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    E1BMS3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane598-622Helical
Transmembrane1035-1053Helical
Transmembrane1086-1103Helical
Transmembrane1147-1165Helical
Transmembrane1177-1203Helical
Transmembrane1215-1237Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-25
ChainPRO_501857474226-1545NAD(P)H oxidase (H2O2-forming)

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region154-173Disordered
Compositional bias157-173Polar residues
Region632-652Disordered
Domain819-854EF-hand
Domain855-890EF-hand
Domain1264-1370FAD-binding FR-type

Sequence similarities

In the N-terminal section; belongs to the peroxidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,545
  • Mass (Da)
    175,106
  • Last updated
    2019-04-10 v2
  • MD5 Checksum
    C5BA77889911996AE814B0B547661C33
MLRARPEVLVLLGVLLSLLLDPTGGQDSLSLTWEVQRYDGWFNNLRHHERGAAGSRLQRLVPANYADGVYQALEEPLLPNPRRLSNAATRGSSGRPSGRNRTVLGVFFGYHVLSDLVSVEKSGCPAEFLNIHIPPGDPVFDRDHSGDVVLPFQRSHWDPETGQSPSNPRDLTNEVTGWLDGSAIYGSSHSWSDELRSFSGGQLASGPDPAFPRAAQAPLLMWMPPDPTTGRRGPRGLYAFGAERGNRDPFLQALGLLWFRYHNLWAQKLARRYPLWGDEELFQHARKRVIATYQNIAMYEWLPSFLQQTPPNYTEYRPFLDPSISPEFLAASEQFFSTMVPPGVYMRNASCHFQMVLNESFGSSPALRVCNSYWIRENPNLNSSQAVNQLLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALQALGLNTPGNWSDLNPNVDPQVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENSRNGLFSPDEIAEIRSTTLRDVVVAVTNVDPDTLQPNVFIWQDGAPCPQPQQLTTGDLPPCVPLTEIHYFEGSGPGFGITIVALCCLPLVSLLISGVVAYFRGRERKKLQRRGKESVKKEPASDGVSAMEWPGPRERSYPVTIQLLPDRRLQVVDRRLSVLRTIQLQPPQQVNLILSSNRRCRTLLLKIPKEYDLVLLFNSQEERGAFVQHLRGFCENWALGLDMAEMSEYELFRKAVTKEQRQRILEIFFRHLFAQVLDINQVDAGTLLLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDVLVVFMKGSPEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLTKTQLAEVVESMFRESGFQDKQELTWEDFHFMLRDHDSELRRTQLCVRGGGGGVGDIFKPNISSRVSFITRTSEERSCPQGVGLPASKAPELGGPGLKKRFGKKAGVPPPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAVFSAICAGLFVERAYYYAFASPPSGIAQTTFVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHVVNVYIFSVSPLSLLACIFPSVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIYFLVPALIYMGDKLVSLSRKKVEIGVVKAQLLPSGVTHLEFQRPQGFEYKSGQWVRIACLALGTNEYHPFTLTSAPHEETLSLHIRAAGPWTTRLREIYSLPTGDSCAKYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFERFFNSLQEVHPKVQKIGVFSCGPPGMTKNVEKACQLINQQDQAHFVHHYENF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias157-173Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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