E1BMS3 · E1BMS3_BOVIN
- ProteinNAD(P)H oxidase (H2O2-forming)
- GeneDUOX2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1545 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Catalytic activity
- NADH + O2 + H+ = H2O2 + NAD+
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | NADPH oxidase complex | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | heme binding | |
Molecular Function | NAD(P)H oxidase H2O2-forming activity | |
Molecular Function | peroxidase activity | |
Molecular Function | superoxide-generating NAD(P)H oxidase activity | |
Biological Process | adenohypophysis morphogenesis | |
Biological Process | bone mineralization | |
Biological Process | defense response | |
Biological Process | fertilization | |
Biological Process | hormone biosynthetic process | |
Biological Process | inner ear development | |
Biological Process | multicellular organism growth | |
Biological Process | organic acid metabolic process | |
Biological Process | response to oxidative stress | |
Biological Process | superoxide anion generation | |
Biological Process | thyroid gland development | |
Biological Process | thyroid hormone generation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H oxidase (H2O2-forming)
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionE1BMS3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 598-622 | Helical | |||
Transmembrane | 1035-1053 | Helical | |||
Transmembrane | 1086-1103 | Helical | |||
Transmembrane | 1147-1165 | Helical | |||
Transmembrane | 1177-1203 | Helical | |||
Transmembrane | 1215-1237 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-25 | ||||
Chain | PRO_5018574742 | 26-1545 | NAD(P)H oxidase (H2O2-forming) | ||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 154-173 | Disordered | |||
Compositional bias | 157-173 | Polar residues | |||
Region | 632-652 | Disordered | |||
Domain | 819-854 | EF-hand | |||
Domain | 855-890 | EF-hand | |||
Domain | 1264-1370 | FAD-binding FR-type | |||
Sequence similarities
In the N-terminal section; belongs to the peroxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,545
- Mass (Da)175,106
- Last updated2019-04-10 v2
- MD5 ChecksumC5BA77889911996AE814B0B547661C33
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 157-173 | Polar residues | |||
Keywords
- Technical term