E1BK87 · E1BK87_BOVIN

  • Protein
    Glutamate receptor
  • Gene
    GRIN3A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for binding site, site.

111151002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site633L-glutamate (UniProtKB | ChEBI)
Binding site638L-glutamate (UniProtKB | ChEBI)
Site777Crucial to convey clamshell closure to channel opening
Binding site801L-glutamate (UniProtKB | ChEBI)
Site807Interaction with the cone snail toxin Con-ikot-ikot
Binding site845L-glutamate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentneuron projection
Cellular Componentneuronal cell body
Cellular ComponentNMDA selective glutamate receptor complex
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density membrane
Cellular Componentpresynapse
Molecular Functioncalcium channel activity
Molecular Functionglutamate receptor activity
Molecular Functionglycine binding
Molecular Functionidentical protein binding
Molecular FunctionNMDA glutamate receptor activity
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Processdendrite development
Biological Processionotropic glutamate receptor signaling pathway
Biological Processmodulation of chemical synaptic transmission
Biological Processprepulse inhibition
Biological Processpresynaptic modulation of chemical synaptic transmission
Biological Processresponse to ethanol
Biological Processsynaptic transmission, glutamatergic

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      GRIN3A

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    E1BK87

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane675-695Helical
Transmembrane716-734Helical
Transmembrane746-769Helical
Transmembrane934-956Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_502716174427-1115Glutamate receptor
Disulfide bond859↔913

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, coiled coil.

TypeIDPosition(s)Description
Region59-118Disordered
Domain557-622Ionotropic glutamate receptor L-glutamate and glycine-binding
Domain565-910Ionotropic glutamate receptor C-terminal
Region1030-1071Disordered
Coiled coil1072-1099

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,115
  • Mass (Da)
    125,110
  • Last updated
    2019-04-10 v3
  • Checksum
    6ABAD5C9CF27A737
MRRLSLWWLLSRVCLLLPPPCALVLAGVPGSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRTPDGSRTGAPRDEPEPGTWLPPAPSPGARWLGSALHGRGPPGARKPGEGARAETLWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSLGEMMELDLVSSVLHIPVISIVRYEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITINLSSTEDLLSFLQVQLESIKNSTPTMVMFGCDMESIRRIFEITTQFGVMLPELRWVLGDSQNVEKLRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALIPSTVNCMDVETANLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQNDPMGKPMWTRLGSWQRGKIVMDYGIWPEQAQRHKTHFQHPSKLNLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSAMLDSLFSSLHSSNDTVPIKLKKCCYGYCIDLLEKLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGSAHLAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRSKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATLDGVAYLKNDPEKLDAFIMDKALLDYEVSVDADCKLLTVGKPFAIEGYGIGLPPNSPFTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFMLLCIGFGLSILTTIGEHMVYRLLLPRIKNKSRLQYWLHTSQRLHRALNTSFVEEKQQRFKTKRVEKRSSVGPRHLTVWNTSNLSHDNRRKYIFNDEGGPNQLGVRTHQDIPLPPRRRELPASLTTNGKADSHSGARNSVIQELSELERQIQVIRQELQLAVSRKTELEEYQRTNRTCEP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9SXX4A0AAA9SXX4_BOVINGRIN3A1007

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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