E1BK87 · E1BK87_BOVIN
- ProteinGlutamate receptor
- GeneGRIN3A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1115 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 633 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 638 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Site | 777 | Crucial to convey clamshell closure to channel opening | ||||
Sequence: L | ||||||
Binding site | 801 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Site | 807 | Interaction with the cone snail toxin Con-ikot-ikot | ||||
Sequence: R | ||||||
Binding site | 845 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | glutamatergic synapse | |
Cellular Component | neuron projection | |
Cellular Component | neuronal cell body | |
Cellular Component | NMDA selective glutamate receptor complex | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | presynapse | |
Molecular Function | calcium channel activity | |
Molecular Function | glutamate receptor activity | |
Molecular Function | glycine binding | |
Molecular Function | identical protein binding | |
Molecular Function | NMDA glutamate receptor activity | |
Molecular Function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | |
Biological Process | dendrite development | |
Biological Process | ionotropic glutamate receptor signaling pathway | |
Biological Process | modulation of chemical synaptic transmission | |
Biological Process | prepulse inhibition | |
Biological Process | presynaptic modulation of chemical synaptic transmission | |
Biological Process | response to ethanol | |
Biological Process | synaptic transmission, glutamatergic |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameGlutamate receptor
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionE1BK87
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 675-695 | Helical | ||||
Sequence: WTMWLGIFVALHITAIFLTLY | ||||||
Transmembrane | 716-734 | Helical | ||||
Sequence: FSSALNVCYALLFGRTAAI | ||||||
Transmembrane | 746-769 | Helical | ||||
Sequence: MNLWAIFCMFCLSTYTANLAAVMV | ||||||
Transmembrane | 934-956 | Helical | ||||
Sequence: LFMLLCIGFGLSILTTIGEHMVY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MRRLSLWWLLSRVCLLLPPPCALVLA | ||||||
Chain | PRO_5027161744 | 27-1115 | Glutamate receptor | |||
Sequence: GVPGSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRTPDGSRTGAPRDEPEPGTWLPPAPSPGARWLGSALHGRGPPGARKPGEGARAETLWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSLGEMMELDLVSSVLHIPVISIVRYEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITINLSSTEDLLSFLQVQLESIKNSTPTMVMFGCDMESIRRIFEITTQFGVMLPELRWVLGDSQNVEKLRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALIPSTVNCMDVETANLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQNDPMGKPMWTRLGSWQRGKIVMDYGIWPEQAQRHKTHFQHPSKLNLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSAMLDSLFSSLHSSNDTVPIKLKKCCYGYCIDLLEKLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGSAHLAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRSKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATLDGVAYLKNDPEKLDAFIMDKALLDYEVSVDADCKLLTVGKPFAIEGYGIGLPPNSPFTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFMLLCIGFGLSILTTIGEHMVYRLLLPRIKNKSRLQYWLHTSQRLHRALNTSFVEEKQQRFKTKRVEKRSSVGPRHLTVWNTSNLSHDNRRKYIFNDEGGPNQLGVRTHQDIPLPPRRRELPASLTTNGKADSHSGARNSVIQELSELERQIQVIRQELQLAVSRKTELEEYQRTNRTCEP | ||||||
Disulfide bond | 859↔913 | |||||
Sequence: CKLLTVGKPFAIEGYGIGLPPNSPFTSNISELISQYKSHGFMDVLHDKWYKVVPC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 59-118 | Disordered | ||||
Sequence: TTAPRAASRTPDGSRTGAPRDEPEPGTWLPPAPSPGARWLGSALHGRGPPGARKPGEGAR | ||||||
Domain | 557-622 | Ionotropic glutamate receptor L-glutamate and glycine-binding | ||||
Sequence: LFSSLHSSNDTVPIKLKKCCYGYCIDLLEKLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLS | ||||||
Domain | 565-910 | Ionotropic glutamate receptor C-terminal | ||||
Sequence: NDTVPIKLKKCCYGYCIDLLEKLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGSAHLAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRSKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATLDGVAYLKNDPEKLDAFIMDKALLDYEVSVDADCKLLTVGKPFAIEGYGIGLPPNSPFTSNISELISQYKSHGFMDVLHDKWYKV | ||||||
Region | 1030-1071 | Disordered | ||||
Sequence: NDEGGPNQLGVRTHQDIPLPPRRRELPASLTTNGKADSHSGA | ||||||
Coiled coil | 1072-1099 | |||||
Sequence: RNSVIQELSELERQIQVIRQELQLAVSR |
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,115
- Mass (Da)125,110
- Last updated2019-04-10 v3
- Checksum6ABAD5C9CF27A737
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SXX4 | A0AAA9SXX4_BOVIN | GRIN3A | 1007 |
Keywords
- Technical term