E1BK52 · STK10_BOVIN
- ProteinSerine/threonine-protein kinase 10
- GeneSTK10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids966 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity).
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Activity regulation
Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib (By similarity).
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 42-50 | ATP (UniProtKB | ChEBI) | |||
Binding site | 65 | ATP (UniProtKB | ChEBI) | |||
Active site | 157 | Proton acceptor | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase 10
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionE1BK52
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000414710 | 1-966 | Serine/threonine-protein kinase 10 | ||
Modified residue | 13 | Phosphoserine | |||
Modified residue | 20 | Phosphoserine | |||
Modified residue | 185 | Phosphothreonine; by autocatalysis | |||
Modified residue | 191 | Phosphoserine; by autocatalysis | |||
Modified residue | 437 | Phosphoserine | |||
Modified residue | 449 | Phosphoserine | |||
Modified residue | 453 | Phosphoserine | |||
Modified residue | 483 | Phosphoserine | |||
Modified residue | 512 | Phosphoserine | |||
Modified residue | 547 | Phosphoserine | |||
Post-translational modification
Autophosphorylates following homodimerization, leading to activation of the protein.
Keywords
- PTM
Proteomic databases
Interaction
Subunit
Homodimer; homodimerization is required for activation segment autophosphorylation.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 36-294 | Protein kinase | |||
Region | 175-224 | Activation segment | |||
Compositional bias | 318-331 | Acidic residues | |||
Region | 318-411 | Disordered | |||
Region | 424-512 | Disordered | |||
Compositional bias | 452-467 | Polar residues | |||
Compositional bias | 486-512 | Polar residues | |||
Coiled coil | 571-945 | ||||
Region | 666-688 | Disordered | |||
Region | 825-863 | Disordered | |||
Compositional bias | 833-863 | Basic and acidic residues | |||
Region | 941-966 | Disordered | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length966
- Mass (Da)111,615
- Last updated2011-12-14 v3
- MD5 Checksum104063F95BD5A2C999997A704E384C80
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 318-331 | Acidic residues | |||
Compositional bias | 452-467 | Polar residues | |||
Compositional bias | 486-512 | Polar residues | |||
Compositional bias | 833-863 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFC03041244 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAFC03048417 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAFC03048418 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAFC03048420 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |