E1BCU9 · E1BCU9_BOVIN

  • Protein
    non-specific serine/threonine protein kinase
  • Gene
    STK11
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site78ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentintracellular protein-containing complex
Cellular Componentmembrane
Cellular Componentmitochondrion
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentserine/threonine protein kinase complex
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular FunctionLRR domain binding
Molecular Functionmagnesium ion binding
Molecular Functionp53 binding
Molecular Functionprotein kinase activator activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processactivation of protein kinase activity
Biological Processanoikis
Biological Processaxonogenesis
Biological Processcellular response to UV-B
Biological Processdendrite extension
Biological ProcessDNA damage response
Biological Processepithelial cell proliferation involved in prostate gland development
Biological Processestablishment of cell polarity
Biological ProcessG1 to G0 transition
Biological Processglucose homeostasis
Biological ProcessGolgi localization
Biological Processintrinsic apoptotic signaling pathway by p53 class mediator
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of cold-induced thermogenesis
Biological Processnegative regulation of epithelial cell proliferation involved in prostate gland development
Biological Processnegative regulation of TORC1 signaling
Biological Processpeptidyl-threonine phosphorylation
Biological Processpositive regulation of autophagy
Biological Processpositive regulation of axonogenesis
Biological Processpositive regulation of protein localization to nucleus
Biological Processpositive regulation of transforming growth factor beta receptor signaling pathway
Biological Processpositive regulation of vesicle transport along microtubule
Biological Processpositive thymic T cell selection
Biological Processprotein autophosphorylation
Biological Processprotein dephosphorylation
Biological Processprotein localization to nucleus
Biological Processregulation of dendrite morphogenesis
Biological Processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processregulation of Wnt signaling pathway
Biological Processresponse to ionizing radiation
Biological Processsignal transduction
Biological ProcessT cell receptor signaling pathway
Biological Processtissue homeostasis
Biological Processvasculature development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    non-specific serine/threonine protein kinase
  • EC number

Gene names

    • Name
      STK11

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    E1BCU9

Proteomes

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-357Protein kinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    564
  • Mass (Da)
    61,871
  • Last updated
    2024-05-29 v4
  • Checksum
    154A2E0C39E22D08
MEVADPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLVDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAEDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYTIPGDCGPPLSDLLRACSGLLPDLALQRGRGSAHMRHALRPHPSQAGAGPLPALTPPPAGLLAGMLEYEPAKRFSIQQIRQHSWFRKKHPPAEQPVPIPPSADCKDRWRGMTVMPYLEDLHGCADDVDDELFDIEDDVIYTQDFTVPGSGGGGWAECTEPGPSQGCVREWHRHHPAEYQVEGRAPGQRRLQPCPQGLLGQQQDPPAVGLQTAMRVAARSPSPGAWPGPAQSSHRQLACCSLPRKAATAPSVLTAPLEARGSWRAVAGGQQGLESGPPSVAGGHNLLLTAILC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9S6M4A0AAA9S6M4_BOVINSTK11413

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp