E1AQY3 · PAMT_CAPAN
- ProteinVanillin aminotransferase
- GeneVAMT
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids459 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Involved in the biosynthesis of capsaicinoids natural products, pungent alkaloids synthesized from phenylpropanoid intermediates in the placental tissue of chili pepper fruit acting as repellant on herbivorous mammals and conferring spiciness to hot peppers (PubMed:35858994).
Can transfer an amine from vanillylamine to pyruvate forming vanillin and L-alanine (By similarity).
Can transfer an amine from vanillylamine to pyruvate forming vanillin and L-alanine (By similarity).
Catalytic activity
- L-alanine + vanillin = pyruvate + vanillylamineThis reaction proceeds in the forward direction.
Pathway
Aromatic compound metabolism; phenylpropanoid biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-aminobutyrate transaminase activity | |
Molecular Function | adenosylmethionine-8-amino-7-oxononanoate transaminase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | biotin biosynthetic process | |
Biological Process | gamma-aminobutyric acid metabolic process | |
Biological Process | phenylpropanoid biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVanillin aminotransferase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Solanoideae > Capsiceae > Capsicum
Accessions
- Primary accessionE1AQY3
- Secondary accessions
Proteomes
Genome annotation databases
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 210 | in strain: cv. Himo and cv. Takanotsume; altered activity leading to reduced pungency of sweeter fruits producing preferentially capsinoids over capsaicinoids | ||||
Sequence: N → K | ||||||
Natural variant | 259 | in strain: cv. Himo; altered activity leading to reduced pungency of sweeter fruits producing preferentially capsinoids over capsaicinoids | ||||
Sequence: C → R | ||||||
Natural variant | 377 | in strain: cv. Himo and cv. Takanotsume; altered activity leading to reduced pungency of sweeter fruits producing preferentially capsinoids over capsaicinoids | ||||
Sequence: A → T | ||||||
Natural variant | 384 | in strain: cv. Himo and cv. Takanotsume; altered activity leading to reduced pungency of sweeter fruits producing preferentially capsinoids over capsaicinoids | ||||
Sequence: N → D |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000458907 | 1-459 | Vanillin aminotransferase | |||
Sequence: MANITNEFMGHDMLAPFTAGWQSDMEPLVIEKSEGSYVYDINGKKYLDTLSGLWCTTLGGSETRLVEAANKQLNTLPFYHSFWNRTTKPSLDLAKELLNMFTANKMAKVFFTNSGSEANDTQVKLVWYYNNALGRPQKKKIIARAKAYHGSTYISAGLSGLPPMHQKFDLPPPFVLHTECPHYWAYHLPGETEEEFSTRLANNLESLILNEGPETVAAFIAEPVLGAAGVILPPATYFDKVQAILRKHDILFIADEVVCGFGRLGTMFGSDKYNIKPDLVSVAKALSSGYMPIAAVLVSQKISSVILSESNKIGAFCHGFTYSGHPVACAVALEALKIYKERNITEVVNKISQKFQEGLKAFADSPIIGEIRGTGLALSTEFVNNKSPNDPFPYEWAVGTYFGAQCAKYGMLVSSTGDHVNMAPPFTLSLEELDELIRIYGKALKDTEKRVEELKSQKK | ||||||
Modified residue | 284 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 430-457 | |||||
Sequence: LEELDELIRIYGKALKDTEKRVEELKSQ |
Sequence similarities
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length459
- Mass (Da)50,728
- Last updated2010-11-02 v1
- Checksum887155DF888C82D4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM991733 EMBL· GenBank· DDBJ | ADM13673.1 EMBL· GenBank· DDBJ | mRNA | ||
LC032105 EMBL· GenBank· DDBJ | BAU36961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC423555 EMBL· GenBank· DDBJ | BBG28790.1 EMBL· GenBank· DDBJ | mRNA | ||
AYRZ02000003 EMBL· GenBank· DDBJ | PHT86213.1 EMBL· GenBank· DDBJ | Genomic DNA |