Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

E0WLS1 · E0WLS1_HRSV

Function

function

Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.
Major determinant of the species specificity of RSV infection. The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate. F protein is involved in the entry into the host cell through the interaction with host IGF1R. This interaction activates PRKCZ/PKCzeta that recruits host NCL/nucleolin to the apical cell surface where it can bind fusion glycoprotein F1. Later in infection, F protein expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. F protein seems to trigger p53-dependent apoptosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell Golgi membrane
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentvirion membrane
Biological Processentry receptor-mediated virion attachment to host cell
Biological Processfusion of virus membrane with host plasma membrane
Biological Processpositive regulation of syncytium formation by virus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fusion glycoprotein F0

Gene names

    • Name
      F

Organism names

  • Taxonomic identifier
  • Strain
    • HRSVs/F/Caen.FRA/53.08
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Pneumoviridae > Orthopneumovirus > Orthopneumovirus hominis

Accessions

  • Primary accession
    E0WLS1

Subcellular Location

Host Golgi apparatus membrane
; Single-pass membrane protein
Host cell membrane
; Single-pass membrane protein
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane137-158Helical

Keywords

Interaction

Subunit

Homotrimer. Heterodimer with fusion protein F1; disulfide-linked. As a heterodimer with F1, interacts with host heparan sulfate. As a heterodimer with F1, interacts with host IGF1R; this interaction activates PRKCZ/PKCzeta that recruits NCL/nucleolin from the host nucleus to the plasma membrane. Part of a complex composed of F1, F2 and G glycoproteins. As a heterodimer with F1, interacts with host RHOA; this interaction facilitates virus-induced syncytium formation.
Homotrimer. Heterodimer with fusion protein F2; disulfide-linked. Interacts with host NCL; this interaction plays a role in viral entry into the host cell. As a heterodimer with F2, interacts with host heparan sulfate. As a heterodimer with F2, interacts with host IGF1R; this interaction activates PRKCZ/PKCzeta that recruits NCL/nucleolin from the host nucleus to the plasma membrane. Part of a complex composed of F1, F2 and G glycoproteins. As a heterodimer with F2, interacts with host RHOA; this interaction facilitates virus-induced syncytium formation.

Structure

Family & Domains

Sequence similarities

Belongs to the paramyxoviruses fusion glycoprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    166
  • Mass (Da)
    18,379
  • Last updated
    2010-11-02 v1
  • MD5 Checksum
    FFE549BDD99951384CFD0C37E485319B
MELPILKTNAITTILAAVTLCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPAANSRARRELPRFMNYTLNNTKNTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue166

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR681658
EMBL· GenBank· DDBJ
CBW45376.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help