E0W544 · AVH23_PHYSO
- ProteinRxLR effector protein Avh23
- GeneAvh23
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids140 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Effector that suppresses plant defense responses during the early stages of pathogen infection. Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:21653195).
Acts as a modulator of histone acetyltransferase (HAT) in plants. Avh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5. As such, Avh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility (PubMed:28318979).
Acts as a modulator of histone acetyltransferase (HAT) in plants. Avh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5. As such, Avh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility (PubMed:28318979).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameRxLR effector protein Avh23
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora
Accessions
- Primary accessionE0W544
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Location into the host nucleus is required for virulence.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Leads to reduced virulence on etiolated soybean hypocotyls.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 109 | Impairs interaction with host ADA2 and subsequent virulence; when associated with A-110, A-112, A-123, A-124 and A-126. | ||||
Sequence: F → A | ||||||
Mutagenesis | 110 | Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-112, A-123, A-124 and A-126. | ||||
Sequence: V → A | ||||||
Mutagenesis | 112 | Impairs interaction with host ADA2 and subsequent virulence; when associated with A-1090, A-110, A-123, A-124 and A-1267. | ||||
Sequence: R → A | ||||||
Mutagenesis | 123 | Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-110, A-112, A-124 and A-126. | ||||
Sequence: F → A | ||||||
Mutagenesis | 124 | Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-110, A-112, A-123 and A-126. | ||||
Sequence: V → A | ||||||
Mutagenesis | 126 | Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-110, A-112, A-123 and A-124. | ||||
Sequence: R → A |
Miscellaneous
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MRLTYFLTVIVVATLHAGGTA | ||||||
Chain | PRO_5007652751 | 22-140 | RxLR effector protein Avh23 | |||
Sequence: LATAEAPNHAAIVNVASADNVHSLDTTAEIGGRMLRKVKEDTVSKKDHEERGPGAILERQTAFVKKLFSRQNAIVNRAQGAFQRQNAFVNRDQGAFQRQNAFVKRAIQRQNHFKLSDNA |
Expression
Induction
Expression is strongly up-regulated during the early stages of infection.
Interaction
Subunit
Interacts with host histone acetyl transferase SAGA complex subunit ADA2.
Structure
Family & Domains
Features
Showing features for motif, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 54-72 | RxLR-dEER | ||||
Sequence: RMLRKVKEDTVSKKDHEER | ||||||
Repeat | 100-113 | ADA2-binding IR1 | ||||
Sequence: QGAFQRQNAFVNRD | ||||||
Repeat | 114-127 | ADA2-binding IR2 | ||||
Sequence: QGAFQRQNAFVKRA |
Domain
The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate.
The two internal repeats IR1 and IR2, in the C-terminus, are required for the interaction with host ADA2.
Sequence similarities
Belongs to the RxLR effector family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length140
- Mass (Da)15,470
- Last updated2010-11-02 v1
- Checksum39B9667D5FD06C4E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JN253688 EMBL· GenBank· DDBJ | AEK80501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN253689 EMBL· GenBank· DDBJ | AEK80502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN253690 EMBL· GenBank· DDBJ | AEK80503.1 EMBL· GenBank· DDBJ | Genomic DNA |