E0W544 · AVH23_PHYSO

Function

function

Effector that suppresses plant defense responses during the early stages of pathogen infection. Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:21653195).
Acts as a modulator of histone acetyltransferase (HAT) in plants. Avh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5. As such, Avh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility (PubMed:28318979).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RxLR effector protein Avh23
  • Alternative names
    • Avirulence homolog protein 23

Gene names

    • Name
      Avh23

Organism names

Accessions

  • Primary accession
    E0W544

Organism-specific databases

Subcellular Location

Secreted
Host nucleus
Host cytoplasm
Note: Location into the host nucleus is required for virulence.

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to reduced virulence on etiolated soybean hypocotyls.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis109Impairs interaction with host ADA2 and subsequent virulence; when associated with A-110, A-112, A-123, A-124 and A-126.
Mutagenesis110Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-112, A-123, A-124 and A-126.
Mutagenesis112Impairs interaction with host ADA2 and subsequent virulence; when associated with A-1090, A-110, A-123, A-124 and A-1267.
Mutagenesis123Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-110, A-112, A-124 and A-126.
Mutagenesis124Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-110, A-112, A-123 and A-126.
Mutagenesis126Impairs interaction with host ADA2 and subsequent virulence; when associated with A-109, A-110, A-112, A-123 and A-124.

Miscellaneous

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500765275122-140RxLR effector protein Avh23

Expression

Induction

Expression is strongly up-regulated during the early stages of infection.

Interaction

Subunit

Interacts with host histone acetyl transferase SAGA complex subunit ADA2.

Structure

Family & Domains

Features

Showing features for motif, repeat.

TypeIDPosition(s)Description
Motif54-72RxLR-dEER
Repeat100-113ADA2-binding IR1
Repeat114-127ADA2-binding IR2

Domain

The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate.
The two internal repeats IR1 and IR2, in the C-terminus, are required for the interaction with host ADA2.

Sequence similarities

Belongs to the RxLR effector family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    140
  • Mass (Da)
    15,470
  • Last updated
    2010-11-02 v1
  • Checksum
    39B9667D5FD06C4E
MRLTYFLTVIVVATLHAGGTALATAEAPNHAAIVNVASADNVHSLDTTAEIGGRMLRKVKEDTVSKKDHEERGPGAILERQTAFVKKLFSRQNAIVNRAQGAFQRQNAFVNRDQGAFQRQNAFVKRAIQRQNHFKLSDNA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN253688
EMBL· GenBank· DDBJ
AEK80501.1
EMBL· GenBank· DDBJ
Genomic DNA
JN253689
EMBL· GenBank· DDBJ
AEK80502.1
EMBL· GenBank· DDBJ
Genomic DNA
JN253690
EMBL· GenBank· DDBJ
AEK80503.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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