E0N9P3 · E0N9P3_NEIME

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site26-33ATP (UniProtKB | ChEBI)
Active site33Proton donor
Binding site57(R)-pantoate (UniProtKB | ChEBI)
Binding site57beta-alanine (UniProtKB | ChEBI)
Binding site144-147ATP (UniProtKB | ChEBI)
Binding site150(R)-pantoate (UniProtKB | ChEBI)
Binding site173ATP (UniProtKB | ChEBI)
Binding site181-184ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      HMPREF0602_1223

Organism names

Accessions

  • Primary accession
    E0N9P3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    278
  • Mass (Da)
    30,908
  • Last updated
    2010-11-02 v1
  • Checksum
    FC0C906D0CD49A65
MQIIHTIQELRAWRKNAGTVAFVPTMGNLHEGHLELVREAKKRADSVVVSIFVNRLQFGQGEDFDKYPRTLQQDADKLEAEGVAVVFAPDEKELYPNVEQRYNVEPPNLQNELCGKFRPGHFLGVATVVSKLFNIVAPDVACFGKKDYQQLAVIKGLTEDLNFDVEIVPVDTGRAEDGLALSSRNQYLSAAERDEAPRLYRELKAVAESLAQGSLDYAGLERQAADHLTAAGWVVDYVEIRHADTLEVARTGDRKLVVLAAARLGTTRLIDNVEIKLP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEEF01000065
EMBL· GenBank· DDBJ
EFM04215.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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