E0N6R3 · E0N6R3_NEIME

  • Protein
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
  • Gene
    murG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13-15UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site125UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site162UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site190UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site244UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site289UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionUDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
Molecular Functionundecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
Biological Processcarbohydrate metabolic process
Biological Processcell division
Biological Processcell wall organization
Biological Processlipid glycosylation
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
  • EC number
  • Alternative names
    • Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase

Gene names

    • Name
      murG
    • ORF names
      HMPREF0602_0193

Organism names

Accessions

  • Primary accession
    E0N6R3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-143Glycosyltransferase family 28 N-terminal
Domain184-328Glycosyl transferase family 28 C-terminal

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    38,157
  • Last updated
    2010-11-02 v1
  • Checksum
    81F4159829BD2CB2
MGGKTFMLMAGGTGGHIFPALAVADSLRARGHHVIWLGSKDSMEERIVPQYGIRLETLAIKGVRGNGIKRKLMLPFTLYQTVREAQRIIRKHRVECVIGFGGFVTFPGGLAAKLLGVPIVIHEQNAVAGLSNRHLSRWAKRVLYAFPKAFSHEGGLVGNPVRADISNLPVPAERFQGREGRLKILVVGGSLGADVLNKTVPQALALLPDNARPQMYHQSGRGKLGSLQADYDALGVKAECVEFITDMVSAYRDADLVICRAGALTIAELTAAGLGALLVPYPHAVDDHQTANARFMVQAEAGLLLPQTQLTAEKLAEILGGLNREKCLKWAENARTLALPHSADDVAEAAIECTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEEF01000007
EMBL· GenBank· DDBJ
EFM05339.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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