E0N6J9 · E0N6J9_NEIME
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids271 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- NADP+ + shikimate = 3-dehydroshikimate + H+ + NADPH
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 19-21 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: SKS | ||||||
Binding site | 66 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 70 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 82 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 91 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 107 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 132-136 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GAGGA | ||||||
Binding site | 156-161 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: NRTRAK | ||||||
Binding site | 215 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: M | ||||||
Binding site | 217 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 239 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 246 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionE0N6J9
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-93 | Shikimate dehydrogenase substrate binding N-terminal | ||||
Sequence: VFGNPVAHSKSPQIHQQFALQEGVDIEYERICADIGGFAQAVSTFFGTGGCGANVTVPFKQEAFHLADEHSDRALAAGAVNTL | ||||||
Domain | 122-191 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | ||||
Sequence: AIEGKTILLLGAGGAVRGVIPVLKEHRPARIVIANRTRAKAEELAQLFGIEAVPMADLNGGFDIIINGTS | ||||||
Domain | 239-265 | SDH C-terminal | ||||
Sequence: GLGMLVGQAAASYALWRGFTPDIRPVI |
Sequence similarities
Belongs to the shikimate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length271
- Mass (Da)28,765
- Last updated2010-11-02 v1
- Checksum3E8F1232A2849919