E0N6J9 · E0N6J9_NEIME

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site19-21shikimate (UniProtKB | ChEBI)
Binding site66shikimate (UniProtKB | ChEBI)
Active site70Proton acceptor
Binding site82NADP+ (UniProtKB | ChEBI)
Binding site91shikimate (UniProtKB | ChEBI)
Binding site107shikimate (UniProtKB | ChEBI)
Binding site132-136NADP+ (UniProtKB | ChEBI)
Binding site156-161NADP+ (UniProtKB | ChEBI)
Binding site215NADP+ (UniProtKB | ChEBI)
Binding site217shikimate (UniProtKB | ChEBI)
Binding site239NADP+ (UniProtKB | ChEBI)
Binding site246shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      HMPREF0602_0129

Organism names

Accessions

  • Primary accession
    E0N6J9

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-93Shikimate dehydrogenase substrate binding N-terminal
Domain122-191Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain239-265SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    28,765
  • Last updated
    2010-11-02 v1
  • Checksum
    3E8F1232A2849919
MTMHALPRYAVFGNPVAHSKSPQIHQQFALQEGVDIEYERICADIGGFAQAVSTFFGTGGCGANVTVPFKQEAFHLADEHSDRALAAGAVNTLILLKNGKLRGDNTDGIGLANDITQVKNIAIEGKTILLLGAGGAVRGVIPVLKEHRPARIVIANRTRAKAEELAQLFGIEAVPMADLNGGFDIIINGTSGGLNGQIPDIPPDIFQNCALAYDMVYGCAAKPFLDFARQSGAKKTADGLGMLVGQAAASYALWRGFTPDIRPVIEYMKAM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEEF01000001
EMBL· GenBank· DDBJ
EFM05507.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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