E0D206 · E0D206_9ACTN

Function

Cofactor

pantetheine 4'-phosphate (UniProtKB | Rhea| CHEBI:47942 )

Features

Showing features for active site.

137995001,0001,5002,0002,5003,0003,500
TypeIDPosition(s)Description
Active site976Proton acceptor; for dehydratase activity
Active site1142Proton donor; for dehydratase activity
Active site2688Proton acceptor; for dehydratase activity
Active site2855Proton donor; for dehydratase activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Function3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Functionfatty acid synthase activity
Molecular Functionphosphopantetheine binding
Biological ProcessDIM/DIP cell wall layer assembly
Biological Processfatty acid biosynthetic process
Biological Processmacrolide biosynthetic process
Biological Processphenol-containing compound biosynthetic process
Biological Processtoxin biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Polyketide synthase

Gene names

    • Name
      gfsE

Organism names

  • Taxonomic identifier
  • Strain
    • A-8890
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    E0D206

Subcellular Location

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain33-459Ketosynthase family 3 (KS3)
Region462-496Disordered
Compositional bias467-486Polar residues
Region944-1069N-terminal hotdog fold
Domain944-1222PKS/mFAS DH
Region1081-1222C-terminal hotdog fold
Domain1652-1730Carrier
Domain1749-2174Ketosynthase family 3 (KS3)
Region2656-2781N-terminal hotdog fold
Domain2656-2936PKS/mFAS DH
Region2794-2936C-terminal hotdog fold
Domain3419-3494Carrier

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,799
  • Mass (Da)
    399,110
  • Last updated
    2010-11-02 v1
  • Checksum
    5A7289213445139B
MTNEDKLRDYLNRVMGELRQSRARLSESEARDHEPIAIIGMSCRFPDGVRSPEDLWRVLVDERHCLTDFPADRGWDLDALYHPDPGHSGTSYTRKGGFLHEAAGFDPEFFGISPREALAMDPQQRLLLETSWEVWERAGLDPAAMRGSRTGVFIGSNDLDYATRLRSVPDGVEGYLATGNLASVLSGRLSYTFGLEGPAVTVDTACSSSLVAMHLAAKALRSDECSLAMVGGVSVMAAPGTFLEFSRQRGLAQDGLCKAFADAADGTGMAEGVGVLLLERLSDARRNGHEVLAVLRGSAVNQDGASNGLTAPNGPSQEQVIRQALDNARLTPDSVDVVEAHGTGTRLGDPIEAEALLATYGQDRPEERPLWLGSVKSNIGHTQAAAGVAGVIKMVMALRQETLPATLHVDRPSTQVDWSSGAVSLLTEARPWARNGRPRRAGVSSFGVSGTNAHAILEEAPAATGNPTEADTDQEPAASASPDRTTTLPAVPWPLSGHTPEALRAQARRLHDTLTTVADGEPQPSPLDLGWSLATTRSTHRHRAVVVGADLPHLLQGVDALASGTPAPHLVRGVAGDTRTAFVFPGQGSQWAGMARELADSSPVFAERLRACEEALAPHVDWSLREVLDGSDLEKADVVQPVLWAVMVSLAALWESHGVRPDAVVGHSQGEIAAACVADALSLEDGARVVALRSRALGVLAGRGGMASLALSAEETTARLAAYKDRLSIAAVNGPHSTVVSGDVEPLHELVAACEADGVRARIVPVDYASHSAHVEEIHDTLLELLAPVTPRPSRVPFFSTVTGEWIDTTVMDAAYWYRNLRRTVQFDVATRTLIAEGFGLLIEASPHPVLAIGMQESVEAAAANCAVLGTLRRGEGGLDRYLLSLGEAHAHGADVDWPAVFAGTGAERVELPTYAFQRRRFWLDGGRDGAGGVASAGLASAGHPLFGAVVEVAGGDRTLLSGRLSVLSHPWLADHSVRGVVLVPGAAFVELALCAGERVGCGAVEELTLQAPLVLPVEGAVQVQFAVEAPDERGHRAFTVYGRSDEAAEPDAWQEYASGVLELEARPEPEGLAQWPPADAEVVPVEGLYDLLGGLGYEYGPAFQGLRRVWRRGEELFAEVSLAEELDGQADQFGIHPALLDGALQTSAVALLQHGGEAAEVRLPFAWRGVSLFATGASAARVRLSPAGQDAVSVLVADQDGVPVARVEGLVSRPVAEEQLGAGGGVGRDSLFGVEWVPFAGGDSDALAADVLEVHRFDGLVQDPQGVREAIERALGLIQGWLARERPRGSRLVVVTRGAVGGEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGDALAGLPADEPHVMVREGQVLVPRLARVVPATEGGAGGVVWDPEKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLEPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGLTGRLAESDLGRLSRQGVLPLSSEQGVALLDAVLATGRPWLVPARLDLGILRTSDQPVPPLLRGLVRRITRRAVTAGANGADSFVQRIAGLSPAEAERAVLELVCGEAAAVLGYASAGAVAPGQAFRELGFDSLTAVELRNRLNGATGLRLPATLIFDYPTPTALATHIRSSAAGTTTGPTAPVAIAGTAVDEAIAIVGMACRYPGGVASPEDLWRLVADEADAVSRFPQDRGWDLDALFDPERPGGTSLTREGGFLYDADQFDAAFFGISPREALAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYGTRVLHVPEEVEGYLGNGNAGSIASGRVAYTFGLEGPAVTVDTACSSSLVTLHLASQALRQGECSLALAGGVTVLATPGVFTEFTRQRGLAEDGRCKAFAAAADGTGWGEGVGMLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLTPADIDLVEAHGTGTRLGDPIEAQALLATYGQDRPEGEPAWLGSVKSNIGHTQAAAGVAGVIKSVMAIRNGVLPASLHVDEPTPEVDWDAGAVELLTEARPWPTTDRPRRAAVSSFGASGTNAHVILEQAADTGPVHAHEGDTTPPSVIAWPISGRDEQALREQAARLGAFVGADASLSAADVGNSLARTRASFEHRAVVVGRDRDELLAGVQALAAGEAAANVVTGRAPAEGAGRVAFVFPGQGSQWIGMGLELAEQSPVFAAALEECGQALAEHVDWDGRSLHEVLRQAEGAPSLERVDVVQPALWAVMVALAAAWRSYGIEPDAVVGHSQGEIAAACVAGVLSVEDGARVVAVRSRAITALAGRGQMVSVPLPEADTVELIRPWADDGQIAVAAVNGPASTVISGDSQAVDALLEKLDAQEIRARRIPVDYASHSPQVALIHDELLRVLDGLTPRAGTVPLFSTVTGQWLGATPMDADYWYRNLRETVRFEAGTRALAAEGWGVFVEASPHPVLTLGIQETLEALDHRGVVTGSLRRQEGGQDRLFVSLAKVHTHGGGPLDRPAFHTGTGAPRVDLPTYAFQRRRYWLEAPAGVPGDLSAAGLQTLEHPLLTGVVDLADEQRTVFTGRLSPATHPWLADHAVFGSVLLPGTGFVELALAAGEHVGHGHLDELTLHAPLFLPEEGAVHLQLVLDGPDTSGRRAVTIHSRAEDEAGGQEWTRHAGGTLAVDADHDTPPALTSWPPADADPVDLTEVYDRFAAAGYAYGPAFQGLRRVWRRDGELFAEVELAGPERDAARRFGVHPALLDAALHPLLLGHGAPQTESEGQGRLPFSWTGVSLRATGATTVRVRLTTDDADTVAVTVTDTAGTPVASVDALVTRPVTAAQFAAGRPSGQSGLFEVEWAPVPTPAAGTASWAVLGGGEVGGVGLGSYDDLAALRRAVDSGAPVPEVVLTFCGGRSETAVVPGTHTATREALALLHEWLADERFAGARLAVVTSGAVAAGPDDEVTDLAAAAVWGLVRSAQSEHPGRFVLLDVDGRAVAGAAVPTALATGEPQVAVRGGELLVPRLARAAKAREVGRDAAGVVWDPEKSLLVTGASGVLAGLTVRHAVSVWGVRHVVLLSRGGADALAQELSEVGVSVRQARCDVADREAVAAVLADIPAAHPLGGVIHTAGVLDDGVIESLTPERLEPVLRPKVDGAWWLHELTAGLDLSVFALFASGAGVFGAAGQGNYAAANAFLDALALHRSRKGLPATALSWGLWAERSGLTGQLTDAELNRMTHHGVLPLSSEQGLALLDSALATDRPWFVPVRIDLGAVRRTGFDHPLLRGLVRVPSRRTVAALDNGTPATDPASLWGRLVALSPAEQEAALLDLVGAQAAAVLGHTDPEQVTTDRPFLDLGFDSLTGVELRNRLTAATGLRLPTTLVFKHRTPAALAAQLRTDLVAVHTDGSGTDTAAPVEAARVPTNGGGTAEAFGELFVEAYRQGRSEEFFRLLRLASEFRPTFDAVRARESVPEPVRLAEGPAEGPDGPMLVCFPSVVGPSGPHQYARFAGPLRDRREVWAVAPPGFVQGELLPKDLATYTDATADAVARRVGETPFVLVGYSSGGWLAHAVASRMEEQGAAPAGVVLLDTYLPEGVVGQLGPELVGGLLERREKFRFDFGDDVWLTAMGGYFRLFDHWRPAAIKAPSLLVRSSEPMPGVPSDTDWRSRWDLPHTAVDVPGNHYTLMEDHAAETARAVRDWVGSLS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias467-486Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB469193
EMBL· GenBank· DDBJ
BAJ16471.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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