E0CXU1 · E0CXU1_MOUSE
- ProteinTransducin-like enhancer of split 3
- GeneTle3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids716 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | Wnt signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE0CXU1
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-77 | Groucho/TLE N-terminal Q-rich | |||
Region | 74-107 | Disordered | |||
Compositional bias | 85-99 | Pro residues | |||
Region | 128-291 | Disordered | |||
Compositional bias | 152-195 | Basic and acidic residues | |||
Compositional bias | 230-245 | Polar residues | |||
Compositional bias | 254-282 | Polar residues | |||
Repeat | 516-557 | WD | |||
Repeat | 558-599 | WD | |||
Sequence similarities
Belongs to the WD repeat Groucho/TLE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length716
- Mass (Da)76,927
- Last updated2010-10-05 v1
- MD5 ChecksumF9288EE88D768C4CA17F9180B759A9D9
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q08122 | TLE3_MOUSE | Tle3 | 772 | ||
Q3TY99 | Q3TY99_MOUSE | Tle3 | 712 | ||
F8WIE2 | F8WIE2_MOUSE | Tle3 | 764 | ||
E0CZB4 | E0CZB4_MOUSE | Tle3 | 53 | ||
F6TS96 | F6TS96_MOUSE | Tle3 | 702 | ||
E0CXS9 | E0CXS9_MOUSE | Tle3 | 767 | ||
E0CY76 | E0CY76_MOUSE | Tle3 | 335 | ||
E0CXS2 | E0CXS2_MOUSE | Tle3 | 760 | ||
E0CY14 | E0CY14_MOUSE | Tle3 | 762 | ||
E0CYI6 | E0CYI6_MOUSE | Tle3 | 81 | ||
E0CYM5 | E0CYM5_MOUSE | Tle3 | 235 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 85-99 | Pro residues | |||
Compositional bias | 152-195 | Basic and acidic residues | |||
Compositional bias | 230-245 | Polar residues | |||
Compositional bias | 254-282 | Polar residues | |||
Keywords
- Technical term