Pet1 knockout leads to significant changes of cell-intrinsic excitability in cortical pyramidal cells and increase in spontaneous synaptic excitation through 5-HT3 receptors.
Findings indicated that while some 5-HT neurons are not absolutely dependent on Pet-1 for expression of Tph2 virtually all dorsal raphe 5-HT neurons require Pet-1 for expression of other key identity genes
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