D9ZDD9 · D9ZDD9_BOVIN

  • Protein
    C-C motif chemokine receptor 2
  • Gene
    CCR2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentexternal side of plasma membrane
Cellular Componentfibrillar center
Molecular FunctionC-C chemokine receptor activity
Molecular FunctionCCR2 chemokine receptor binding
Molecular Functionchemokine (C-C motif) ligand 12 binding
Molecular Functionchemokine (C-C motif) ligand 2 binding
Molecular Functionchemokine (C-C motif) ligand 7 binding
Biological Processblood vessel remodeling
Biological Processcellular defense response
Biological Processcellular homeostasis
Biological Processhemopoiesis
Biological Processhomeostasis of number of cells within a tissue
Biological Processhumoral immune response
Biological Processinflammatory response to wounding
Biological Processleukocyte adhesion to vascular endothelial cell
Biological Processmacrophage migration
Biological Processmonocyte chemotaxis
Biological Processmonocyte extravasation
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of eosinophil degranulation
Biological Processnegative regulation of type 2 immune response
Biological Processneutrophil clearance
Biological Processpositive regulation of alpha-beta T cell proliferation
Biological Processpositive regulation of astrocyte chemotaxis
Biological Processpositive regulation of CD8-positive, alpha-beta T cell extravasation
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of hematopoietic stem cell migration
Biological Processpositive regulation of immune complex clearance by monocytes and macrophages
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of leukocyte tethering or rolling
Biological Processpositive regulation of monocyte chemotaxis
Biological Processpositive regulation of monocyte extravasation
Biological Processpositive regulation of synaptic transmission, glutamatergic
Biological Processpositive regulation of T cell chemotaxis
Biological Processpositive regulation of T-helper 1 type immune response
Biological Processpositive regulation of thymocyte migration
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of type II interferon production
Biological Processregulation of macrophage migration
Biological Processregulation of T cell cytokine production
Biological Processregulation of T cell differentiation
Biological Processregulation of vascular endothelial growth factor production
Biological Processsensory perception of pain
Biological ProcessT-helper 17 cell chemotaxis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • C-C motif chemokine receptor 2
    • Chemokine (C-C motif) receptor 2

Gene names

    • Name
      CCR2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    D9ZDD9
  • Secondary accessions
    • F1MTU8

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane58-78Helical
Transmembrane90-109Helical
Transmembrane129-151Helical
Transmembrane163-189Helical
Transmembrane218-240Helical
Transmembrane252-278Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain69-315G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    370
  • Mass (Da)
    41,916
  • Last updated
    2010-10-05 v1
  • Checksum
    DF9E35CCD5750256
MDGNDTFSHNVLPTSHSLFTTNVKGNDEEPTTSYDYDYSEPCRKTSVGQIEAQLLPPLYSLVFIFGFVGNLLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTMPFWAHYAADQWVFGNVMCKFFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSGVTWVVAVFASLPGIIFIKSLEEHSGYACAPYFPLGWKNFHTIMRSILGLVLPLLVMIICYSGIIKTLLRCRNEKKKHKAVRLIFVIMIVYFLFWAPYNIVLLLSTFQEFFGLSNCKSSSQLDQAMQVTETLGLTHCCINPIIYAFVGEKFRRYLSTFFRKHIAKHLCKQCPVFYGETGDRVSSTYTHSTGEQEVSAAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU936960
EMBL· GenBank· DDBJ
ADD82797.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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