D9QEP1 · D9QEP1_CORP2

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site131ATP (UniProtKB | ChEBI)
Binding site214ATP (UniProtKB | ChEBI)
Binding site249ATP (UniProtKB | ChEBI)
Active site306
Binding site546Mn2+ (UniProtKB | ChEBI)
Binding site618substrate
Binding site716Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site745Mn2+ (UniProtKB | ChEBI)
Binding site747Mn2+ (UniProtKB | ChEBI)
Binding site880substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionbiotin carboxylase activity
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      CPC231_02405

Organism names

Accessions

  • Primary accession
    D9QEP1

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue716N6-carboxylysine
Modified residue1107N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-463Biotin carboxylation
Domain135-331ATP-grasp
Domain537-806Pyruvate carboxyltransferase
Domain1064-1141Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,141
  • Mass (Da)
    122,684
  • Last updated
    2010-10-05 v1
  • Checksum
    072670CDCBB69E44
MHHSTQKTATHHPTSFSKILVANRGEIAVRAFRAAFETGASTVAVYPMEDRNSFHRSFASEAVLIGEGGSAVKAYLDIDEVIRAAKQTGADAVYPGYGFLSENARLARECAENGLTFIGPPPSVLDLTGDKSAAVAAAREAGLPTLTETEPTDDPKELAILSKDQVYPLFVKAVAGGGGRGMRFVEKPEDLEKLAAEASREAAAAFGDGRVYAERAVINPQHIEVQILGDAEGNIVHLYERDCSLQRRHQKVVEIAPAQHLDPDLRDKICADAVAFARHIGYMGAGTVEFLVDEDGNHVFIEMNPRIQVEHTVTEEVTQVDLVKSQIMIAAGATLEQLGLRQEDIHTEGAALQCRITTEDPNNGFRPDTGTITAYRSPGGAGVRLDGAAMLGGEISPNFDSMLVKMTCRGADFETAVARAQRALAEFVVSGVATNIGFLRALLREEDFQSKRIATGFIADHPWLLQAPPADDEQGRILDYLADVTVNKPHGIRPAVVNPVEKLPVESKGKLPRGSRDRLLQMGPVEFARALRKQDALAVTDTTFRDAHQSLLATRVRSNTLIDAARHVARLTPELLSVEAWGGATYDVAMRFLHEDPWERLDHLREAMPNINIQMLLRGRNTVGYTPYPDSVCAAFVNEAARSGVDVFRIFDALNDVSQMRPAIDAVLNTGTTVAEVAMAYSGDLTNPKEKLYTLDYYLNLAEQIVDSGAHILAVKDMAGLMKPAAATKLVTELRKNFDLPVHVHTHDTAGGQLATYWAAAAAGADAVDGASAPLSGTTSQPSLSAIVAAFDNTYRSTGLSLDAVGSLEPYWEAVRKLYAPFESGTPGPTGRVYLHEIPGGQLSNLRAQATALGLADRFELIEDTYAAVNEMLGRPTKVTPSSKVVGDLALYLVGAGVDPKDFAADPQKYDIPDSVIAFLRGELGTPPGGWPEELRNKALSGRKESKDTLAELPAEEAAALADQATVRGTLDRLLFPKPAQEFSEHRRQFGDTTKLGDAEFLYGLVEGKETVIHTADNNVPMIVRLDAVGEPDEKGMRNVVCNVNGQIRPILVRDRSVESITASAEKADTANVGHVAAPFSGVVTVTAEPGANVAAGDPVAVIEAMKMEATISATKDGTIERIVMTQPTKVEGGDLLLVIS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001829
EMBL· GenBank· DDBJ
ADL09964.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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