D9Q064 · D9Q064_ACIS3

Function

function

ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.

Features

Showing features for binding site.

138850100150200250300350
TypeIDPosition(s)Description
Binding site177-182ATP (UniProtKB | ChEBI)
Binding site316ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentproteasome regulatory particle, base subcomplex
Cellular Componentproteasome-activating nucleotidase complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionproteasome-activating activity
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein unfolding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Proteasome-activating nucleotidase
  • Short names
    PAN
  • Alternative names
    • Proteasomal ATPase
    • Proteasome regulatory ATPase
    • Proteasome regulatory particle

Gene names

    • Name
      pan
    • Ordered locus names
      ASAC_0295

Organism names

Accessions

  • Primary accession
    D9Q064

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain166-305AAA+ ATPase

Domain

Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.

Sequence similarities

Belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    388
  • Mass (Da)
    43,325
  • Last updated
    2010-10-05 v1
  • Checksum
    D9565B32BD868432
MSLSESGKNTREKPDDDELSLLREKVRYLTQLNMNLEKDLEFYKQELNKLLEPPYIEAMVLEVLSDGRAVVKSSTGPNLVVRIASNVDIDKLRPGASVALNNKGSTIVEVLPSIHDPLVEAMEIEERPSITFKDVGGLEEQIREIYEVVGLPLIKPQLFDEIGVEPPKGVLLYGPPGTGKTLVARALAGEVKATFIRVVASQFVNKFIGEGARIVREVFRLAKEKKPSIIFIDEIDAIGSRRVDMGTSGDREVQRTMLQLLAEMDGFDPLEGVKVVAATNRIDLLDPALLRPGRFDRIIEIPLPDKKGRLEILKIHTRNMKLKDVDLEEIASMTEGFSGAELKAVATEAGFFAIRDGKNYVSQEHFIKAVDKVRNRMEKRKQIFGTHI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001742
EMBL· GenBank· DDBJ
ADL18702.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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