D9PVI7 · MDH_METTM

Function

function

Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD+ and NADP+ with similar specific activity.

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.03 mMoxaloacetate
0.09 mMNADH
0.02 mMNADPH
1 mMmalate
0.5 mMNAD+

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-13NADP+ (UniProtKB | ChEBI)
Binding site84substrate
Binding site90substrate
Binding site97NADP+ (UniProtKB | ChEBI)
Binding site120-122NADP+ (UniProtKB | ChEBI)
Binding site122substrate
Binding site153substrate
Active site177Proton acceptor

GO annotations

AspectTerm
Molecular FunctionL-malate dehydrogenase activity
Molecular Functionmalate dehydrogenase (NADP+) activity
Biological Processcarboxylic acid metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malate dehydrogenase
  • EC number
  • Alternative names
    • MdhII

Gene names

    • Name
      mdh
    • Ordered locus names
      MTBMA_c06400

Organism names

Accessions

  • Primary accession
    D9PVI7

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004360351-325Malate dehydrogenase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the LDH/MDH superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    325
  • Mass (Da)
    35,860
  • Last updated
    2010-10-05 v1
  • Checksum
    1D4BB57775D4A236
MKVSIIGSTGRVGRATALCLAEEEAVKTLHLISRRESLEQNIGEVLDMSDALAAKGVSVKLENSADIENVHGSRIVVITAGVPRTADMDRDDLAFQNGVIVAEYARQIARFAPDSIILVVTNPVDVMTYVALKYSGFHPSRVFGLGNHLDSLRLKNYMARHFNVHVSEVHTRVIGQHGPYMVPLISSTSIGGIPIEHYARRDYFSGYRRFDLKKTIEKVINAGSNIISRKGATEYGPAFAISNIVTTILNDERRILTVSTLMEGEIDGIRDVCLGVPVKLGKNGIEGVVPVLMDRDERETFREAASHVRNSTMKVMEFLDEELPL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict1in Ref. 2; AA sequence
Sequence conflict19in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001710
EMBL· GenBank· DDBJ
ADL58235.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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