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D9D7Z3 · D9D7Z3_9DIPT

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    CO1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CO1
    • Synonyms
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BasqueCoast-1
    • BasqueCoast-10
    • BasqueCoast-11
    • BasqueCoast-12
    • BasqueCoast-13
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Chironomidae > Clunio

Accessions

  • Primary accession
    D9D7Z3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane29-52Helical
Transmembrane64-87Helical
Transmembrane99-120Helical
Transmembrane140-161Helical
Transmembrane173-191Helical
Transmembrane211-234Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-273Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    273
  • Mass (Da)
    30,823
  • Last updated
    2010-10-05 v1
  • MD5 Checksum
    CF1C9F3115E4AD0AB4E489F6C2BA1652
HPEVYILILPGFGMISHIISQESGKKETFGALGMIYAMLAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATIHGTQMNNSPSLLWTLGFIFLFTVGGLTGVILANSSIDIILHDTYYVVAHFHYVLSMGAVFAIMAGFVHWYPLFSGLMMNDNWLKSQFYIMFLGVNLTFFPQHFLGLAGMPRRYSDYPDAYSSWNIISTLGSTISLLGIIMFLMIMWESMITLRIPLYSMNLTSSIEWYQKMPPLEHSYSELPMLT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU943236
EMBL· GenBank· DDBJ
ADJ67739.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943237
EMBL· GenBank· DDBJ
ADJ67740.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943239
EMBL· GenBank· DDBJ
ADJ67742.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943240
EMBL· GenBank· DDBJ
ADJ67743.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943241
EMBL· GenBank· DDBJ
ADJ67744.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943242
EMBL· GenBank· DDBJ
ADJ67745.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943246
EMBL· GenBank· DDBJ
ADJ67749.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943248
EMBL· GenBank· DDBJ
ADJ67751.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943249
EMBL· GenBank· DDBJ
ADJ67752.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943250
EMBL· GenBank· DDBJ
ADJ67753.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943251
EMBL· GenBank· DDBJ
ADJ67754.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943252
EMBL· GenBank· DDBJ
ADJ67755.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943253
EMBL· GenBank· DDBJ
ADJ67756.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943254
EMBL· GenBank· DDBJ
ADJ67757.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943255
EMBL· GenBank· DDBJ
ADJ67758.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943256
EMBL· GenBank· DDBJ
ADJ67759.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943257
EMBL· GenBank· DDBJ
ADJ67760.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943258
EMBL· GenBank· DDBJ
ADJ67761.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943259
EMBL· GenBank· DDBJ
ADJ67762.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943260
EMBL· GenBank· DDBJ
ADJ67763.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943261
EMBL· GenBank· DDBJ
ADJ67764.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943262
EMBL· GenBank· DDBJ
ADJ67765.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943263
EMBL· GenBank· DDBJ
ADJ67766.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943264
EMBL· GenBank· DDBJ
ADJ67767.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943265
EMBL· GenBank· DDBJ
ADJ67768.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943266
EMBL· GenBank· DDBJ
ADJ67769.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943267
EMBL· GenBank· DDBJ
ADJ67770.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943268
EMBL· GenBank· DDBJ
ADJ67771.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943269
EMBL· GenBank· DDBJ
ADJ67772.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943270
EMBL· GenBank· DDBJ
ADJ67773.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943271
EMBL· GenBank· DDBJ
ADJ67774.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943272
EMBL· GenBank· DDBJ
ADJ67775.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943273
EMBL· GenBank· DDBJ
ADJ67776.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943274
EMBL· GenBank· DDBJ
ADJ67777.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943275
EMBL· GenBank· DDBJ
ADJ67778.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943276
EMBL· GenBank· DDBJ
ADJ67779.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943277
EMBL· GenBank· DDBJ
ADJ67780.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943278
EMBL· GenBank· DDBJ
ADJ67781.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943279
EMBL· GenBank· DDBJ
ADJ67782.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943280
EMBL· GenBank· DDBJ
ADJ67783.1
EMBL· GenBank· DDBJ
Genomic DNA
GU943281
EMBL· GenBank· DDBJ
ADJ67784.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851805
EMBL· GenBank· DDBJ
CRL08769.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851806
EMBL· GenBank· DDBJ
CRL08770.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851807
EMBL· GenBank· DDBJ
CRL08771.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851808
EMBL· GenBank· DDBJ
CRL08772.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851810
EMBL· GenBank· DDBJ
CRL08774.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851811
EMBL· GenBank· DDBJ
CRL08775.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851812
EMBL· GenBank· DDBJ
CRL08776.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851813
EMBL· GenBank· DDBJ
CRL08777.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851816
EMBL· GenBank· DDBJ
CRL08780.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851817
EMBL· GenBank· DDBJ
CRL08781.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851818
EMBL· GenBank· DDBJ
CRL08782.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851819
EMBL· GenBank· DDBJ
CRL08783.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851823
EMBL· GenBank· DDBJ
CRL08787.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851825
EMBL· GenBank· DDBJ
CRL08789.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851826
EMBL· GenBank· DDBJ
CRL08790.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851827
EMBL· GenBank· DDBJ
CRL08791.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851828
EMBL· GenBank· DDBJ
CRL08792.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851829
EMBL· GenBank· DDBJ
CRL08793.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851830
EMBL· GenBank· DDBJ
CRL08794.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851831
EMBL· GenBank· DDBJ
CRL08795.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851832
EMBL· GenBank· DDBJ
CRL08796.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851834
EMBL· GenBank· DDBJ
CRL08798.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851836
EMBL· GenBank· DDBJ
CRL08800.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851837
EMBL· GenBank· DDBJ
CRL08801.1
EMBL· GenBank· DDBJ
Genomic DNA
LN851838
EMBL· GenBank· DDBJ
CRL08802.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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