D9D7Z3 · D9D7Z3_9DIPT
- ProteinCytochrome c oxidase subunit 1
- GeneCO1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Chironomidae > Clunio
Accessions
- Primary accessionD9D7Z3
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 29-52 | Helical | |||
Transmembrane | 64-87 | Helical | |||
Transmembrane | 99-120 | Helical | |||
Transmembrane | 140-161 | Helical | |||
Transmembrane | 173-191 | Helical | |||
Transmembrane | 211-234 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Sequence
- Sequence statusFragment
- Length273
- Mass (Da)30,823
- Last updated2010-10-05 v1
- MD5 ChecksumCF1C9F3115E4AD0AB4E489F6C2BA1652
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU943236 EMBL· GenBank· DDBJ | ADJ67739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943237 EMBL· GenBank· DDBJ | ADJ67740.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943239 EMBL· GenBank· DDBJ | ADJ67742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943240 EMBL· GenBank· DDBJ | ADJ67743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943241 EMBL· GenBank· DDBJ | ADJ67744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943242 EMBL· GenBank· DDBJ | ADJ67745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943246 EMBL· GenBank· DDBJ | ADJ67749.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943248 EMBL· GenBank· DDBJ | ADJ67751.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943249 EMBL· GenBank· DDBJ | ADJ67752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943250 EMBL· GenBank· DDBJ | ADJ67753.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943251 EMBL· GenBank· DDBJ | ADJ67754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943252 EMBL· GenBank· DDBJ | ADJ67755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943253 EMBL· GenBank· DDBJ | ADJ67756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943254 EMBL· GenBank· DDBJ | ADJ67757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943255 EMBL· GenBank· DDBJ | ADJ67758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943256 EMBL· GenBank· DDBJ | ADJ67759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943257 EMBL· GenBank· DDBJ | ADJ67760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943258 EMBL· GenBank· DDBJ | ADJ67761.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943259 EMBL· GenBank· DDBJ | ADJ67762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943260 EMBL· GenBank· DDBJ | ADJ67763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943261 EMBL· GenBank· DDBJ | ADJ67764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943262 EMBL· GenBank· DDBJ | ADJ67765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943263 EMBL· GenBank· DDBJ | ADJ67766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943264 EMBL· GenBank· DDBJ | ADJ67767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943265 EMBL· GenBank· DDBJ | ADJ67768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943266 EMBL· GenBank· DDBJ | ADJ67769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943267 EMBL· GenBank· DDBJ | ADJ67770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943268 EMBL· GenBank· DDBJ | ADJ67771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943269 EMBL· GenBank· DDBJ | ADJ67772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943270 EMBL· GenBank· DDBJ | ADJ67773.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943271 EMBL· GenBank· DDBJ | ADJ67774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943272 EMBL· GenBank· DDBJ | ADJ67775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943273 EMBL· GenBank· DDBJ | ADJ67776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943274 EMBL· GenBank· DDBJ | ADJ67777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943275 EMBL· GenBank· DDBJ | ADJ67778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943276 EMBL· GenBank· DDBJ | ADJ67779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943277 EMBL· GenBank· DDBJ | ADJ67780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943278 EMBL· GenBank· DDBJ | ADJ67781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943279 EMBL· GenBank· DDBJ | ADJ67782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943280 EMBL· GenBank· DDBJ | ADJ67783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU943281 EMBL· GenBank· DDBJ | ADJ67784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851805 EMBL· GenBank· DDBJ | CRL08769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851806 EMBL· GenBank· DDBJ | CRL08770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851807 EMBL· GenBank· DDBJ | CRL08771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851808 EMBL· GenBank· DDBJ | CRL08772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851810 EMBL· GenBank· DDBJ | CRL08774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851811 EMBL· GenBank· DDBJ | CRL08775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851812 EMBL· GenBank· DDBJ | CRL08776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851813 EMBL· GenBank· DDBJ | CRL08777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851816 EMBL· GenBank· DDBJ | CRL08780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851817 EMBL· GenBank· DDBJ | CRL08781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851818 EMBL· GenBank· DDBJ | CRL08782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851819 EMBL· GenBank· DDBJ | CRL08783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851823 EMBL· GenBank· DDBJ | CRL08787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851825 EMBL· GenBank· DDBJ | CRL08789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851826 EMBL· GenBank· DDBJ | CRL08790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851827 EMBL· GenBank· DDBJ | CRL08791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851828 EMBL· GenBank· DDBJ | CRL08792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851829 EMBL· GenBank· DDBJ | CRL08793.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851830 EMBL· GenBank· DDBJ | CRL08794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851831 EMBL· GenBank· DDBJ | CRL08795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851832 EMBL· GenBank· DDBJ | CRL08796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851834 EMBL· GenBank· DDBJ | CRL08798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851836 EMBL· GenBank· DDBJ | CRL08800.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851837 EMBL· GenBank· DDBJ | CRL08801.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN851838 EMBL· GenBank· DDBJ | CRL08802.1 EMBL· GenBank· DDBJ | Genomic DNA |