D9D7M8 · D9D7M8_AKOMN

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Sigmodontinae > Akodon

Accessions

  • Primary accession
    D9D7M8

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane43-64Helical
Transmembrane85-109Helical
Transmembrane129-152Helical
Transmembrane164-191Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-221Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    221
  • Mass (Da)
    23,763
  • Last updated
    2010-10-05 v1
  • Checksum
    D014A5849E913E2D
LIFGAWAGMVGTALSILIRAELGQPGALMGDDQIYNVVVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue221

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU938874
EMBL· GenBank· DDBJ
ADJ57187.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938875
EMBL· GenBank· DDBJ
ADJ57188.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938913
EMBL· GenBank· DDBJ
ADJ57224.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938927
EMBL· GenBank· DDBJ
ADJ57238.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938928
EMBL· GenBank· DDBJ
ADJ57239.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938929
EMBL· GenBank· DDBJ
ADJ57240.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938930
EMBL· GenBank· DDBJ
ADJ57241.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938932
EMBL· GenBank· DDBJ
ADJ57243.1
EMBL· GenBank· DDBJ
Genomic DNA
GU938934
EMBL· GenBank· DDBJ
ADJ57245.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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