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D8VK86 · D8VK86_HELCY

Function

function

Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.

Features

Showing features for binding site, active site.

130320406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site83CoA (UniProtKB | ChEBI)
Active site121Proton donor/acceptor
Binding site126CoA (UniProtKB | ChEBI)
Binding site130CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydroxymethylglutaryl-CoA synthase activity
Biological Processacetyl-CoA metabolic process
Biological Processfarnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Processsterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxymethylglutaryl-CoA synthase
  • EC number
  • Short names
    HMG-CoA synthase
  • Alternative names
    • 3-hydroxy-3-methylglutaryl coenzyme A synthase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Papilionoidea > Nymphalidae > Heliconiinae > Heliconiini > Heliconius

Accessions

  • Primary accession
    D8VK86

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-48Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Domain49-303Hydroxymethylglutaryl-coenzyme A synthase C-terminal

Sequence similarities

Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    303
  • Mass (Da)
    33,693
  • Last updated
    2010-10-05 v1
  • MD5 Checksum
    873CC702A5EC1041E2EEC774663BC1D9
CINWVGASSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVRASYMTHAYDFYKPDLASEFPYVDGKLSIHCYLSALDNCYNLFCKKMRNVDPNFKGLLSLDGMLFHSPYCKLVQKSLARVCFNDFLNAEEGEREKQFPGLSQFNSYQRENTYFDRDVEKAFMTYSKELFDDKTKPSLYVARNVGNMYTSSLYGGLVSYLVSKSADQLIGKKFALFSYGSGLASTMYSINICNDMSAGSKLEKLINSLHENVQMLNKRVAVAPQMFSDLMQVRTENYHTAPYEPSGSID

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue303

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ987493
EMBL· GenBank· DDBJ
ADI81160.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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