D8VK86 · D8VK86_HELCY
- ProteinHydroxymethylglutaryl-CoA synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids303 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
Catalytic activity
- acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H+
Pathway
Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 83 | CoA (UniProtKB | ChEBI) | |||
Active site | 121 | Proton donor/acceptor | |||
Binding site | 126 | CoA (UniProtKB | ChEBI) | |||
Binding site | 130 | CoA (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydroxymethylglutaryl-CoA synthase activity | |
Biological Process | acetyl-CoA metabolic process | |
Biological Process | farnesyl diphosphate biosynthetic process, mevalonate pathway | |
Biological Process | sterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHydroxymethylglutaryl-CoA synthase
- EC number
- Short namesHMG-CoA synthase
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Papilionoidea > Nymphalidae > Heliconiinae > Heliconiini > Heliconius
Accessions
- Primary accessionD8VK86
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-48 | Hydroxymethylglutaryl-coenzyme A synthase N-terminal | |||
Domain | 49-303 | Hydroxymethylglutaryl-coenzyme A synthase C-terminal | |||
Sequence similarities
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length303
- Mass (Da)33,693
- Last updated2010-10-05 v1
- MD5 Checksum873CC702A5EC1041E2EEC774663BC1D9
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 303 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GQ987493 EMBL· GenBank· DDBJ | ADI81160.1 EMBL· GenBank· DDBJ | Genomic DNA |