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D8QDU9 · D8QDU9_SCHCM

Function

function

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Catalytic activity

Activity regulation

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone H3K79 trimethyltransferase activity
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • EC number
  • Alternative names
    • Histone H3-K79 methyltransferase

Gene names

    • ORF names
      SCHCODRAFT_112035

Organism names

Accessions

  • Primary accession
    D8QDU9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for coiled coil, repeat, domain.

Type
IDPosition(s)Description
Coiled coil153-187
Repeat741-769ANK
Repeat847-879ANK
Domain1057-1388DOT1

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,388
  • Mass (Da)
    157,511
  • Last updated
    2010-10-05 v1
  • MD5 Checksum
    30BB76C42AB2A80FE59E776F820EC4B0
MDPGTILAVIDMAGKVTVALCKYASSAKGADKARLALWRELSSISGTLMNVKYYFESLADGFAPETQKRMNALRLWEEGGPIKECMKLLDNFLRELDVDMKKQGLKRKLLWPFKEETIEEFLKQLERHKAHLMLAFSINTSEQLTDIAQISFMIAEEQARVRLEKEIADTQRASQEESRRRDSLRDEIIRWLQPVDNGSKHAISLQKRQEGTCKWIFTHDTYRQWSTRESGMLWLSGIPGSGKSVMASSLIDALRQKRYPALVYHYCDFGDPSSTSVVSILRSLFVQLLRNAPPAWFDELNSIANQVKSGEPPSSILEVYGYVQRAVPLYPEQLFIIDALDECQEPAELIRFLVRLSELGGVHVFVTSRNERAIYELLQDTPTISLTDEKDLVNADIREHVVRSLATTPGLSRLPSNIKKEIEVALLSKADCMFRWVECQLDFLATCRTRQAVNHALNNLPKTLYETYERILQAIDRQGTDMARIAQHTLRWLVGAQRPIRLNEIQEAVMIEVGEDSLNEDLGVFDPMDVLHTCSSLVSYDNAKGVVNLSHFTVQEYLLVPSLATSTLSHFSVQLVDLHRDLALQCLTYISFDNFAGGACYDKPSYMARLRNHPLFDYVAHHWTDHVAQVRAYDAEVYASIDDLLFSEKKRPHCLAFRQNEQGAESQFTSKRAFEIYDKAWWTHPSYANQKMKDRQAPGSFLLPAPSWWYAIKTRQTWLAERMFHDHPSLITSEYPYIGFPLMATARHGLPEVARILLDMGADVNAACDCNKEVPRTALYSAVEHMTRDPGHLATFRLLLERGAEVNRRYGEVRDTVLQCAAALGDRIEAMRLLLERGADREASNAYGETSLHIAVRSDSLDTVEFLLGVGCNVNARTYSGKDALQMALEMRSPKVVQCLLERGPDLSQLHFAAEDLDWARGQPWSPTIVSGLMRSKPMSDAGLQEVYDTLRRGGVPEELVLDILDLAELWSCSSASRAQKVAVDSRTQSYVYAELEVPDAPLRSLTFVTVSHDQGWSDYEDDHGTYRRSSTWFEAGVKGSDARRLIQQNIHASSDRRLHTNTWSFDTPDPELQEWLRGMQGGRFLQLIARAQYQGWVNHVYSAEIRVFSRFSPERRLSSTERSRKWRQDPLNRAWENANRVMQRRAETKGLKWKCPKRREVKYSTCVVTRHRTRQIPKATKPTQDEDALERCRHLCPPFLQDLLTELSLTGESTFVHLGSGMGGAVIQAAFQTGCQAYGIELDPHLYSTSIELSYSARLQCERTQQEIGPTTFENACVYSANLLPSLVSSADLVLVDNDAFDATLVDHLFRWIVLIMKHGSVIAASKPLTGGPETPSVLYTAEHNEDIYVYANLGIRVHVLKRTRAESLTTSWSTGGSYFLHRVCKD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1388

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL377310
EMBL· GenBank· DDBJ
EFI93744.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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