D8QDU9 · D8QDU9_SCHCM
- ProteinHistone-lysine N-methyltransferase, H3 lysine-79 specific
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1388 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous
In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Catalytic activity
- L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
Activity regulation
Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone H3K79 trimethyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase, H3 lysine-79 specific
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Schizophyllaceae > Schizophyllum
Accessions
- Primary accessionD8QDU9
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for coiled coil, repeat, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 153-187 | ||||
Repeat | 741-769 | ANK | |||
Repeat | 847-879 | ANK | |||
Domain | 1057-1388 | DOT1 | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,388
- Mass (Da)157,511
- Last updated2010-10-05 v1
- MD5 Checksum30BB76C42AB2A80FE59E776F820EC4B0
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1388 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GL377310 EMBL· GenBank· DDBJ | EFI93744.1 EMBL· GenBank· DDBJ | Genomic DNA |