D8KZD5 · D8KZD5_COTVE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    D8KZD5

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-35Helical
Transmembrane55-81Helical
Transmembrane102-126Helical
Transmembrane146-169Helical
Transmembrane181-208Helical
Transmembrane241-257Helical
Transmembrane269-289Helical
Transmembrane301-323Helical
Transmembrane335-355Helical
Transmembrane375-395Helical
Transmembrane407-428Helical
Transmembrane448-471Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-510Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    58,225
  • Last updated
    2010-10-05 v1
  • Checksum
    8F91584ABF811949
MMKWLMSTNHKDIGMLYFMFGLWSGMLGFSMSLIIRLELGMPGSLIGNDQIYNSIVTSHAFIMIFFMVMPVMIGGFGNWLIPLMLGSPDMSFPRMNNMSFWLLIPSLLLLILSSFINVGVGTGWTVYPPLSLILGHGGMSVDLGIFSLHLAGASSIMGAVNFITTIMNMRSNLFNMDKMSLFSWSVFITAILLLLSLPVLAGAITMLLTDRNMNTSFFDPSGGGDPILYQHLFWFFGHPEVYILILPGFGIISHMIFNESGKKETFGMLGMIYAMLTIGFLGFIVWAHHMFTIGMDVDTRAYFTSATMIIAIPTGIKIFSWMATFSGVKLINNLMILWTMGFIFLFTVGGLTGVVLSNSSVDVVLHDTYYVVAHFHYVLSMGAVFSILGGFIYWFPMFFGLMMNEYFLKIHFYLTFIGVNLIFFPQHFLGLSGMPRRYSDYPDMYLNWNLFSSFGSLISLVGVFLFIFIIWESLIMQRFVIFVKFINSSIEWFHLYPPLDHSYDETLKVSIKLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ154897
EMBL· GenBank· DDBJ
ACH71087.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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