D7WCS3 · D7WCS3_9CORY
- ProteinATP phosphoribosyltransferase
- GenehisG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids283 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
Cofactor
Activity regulation
Feedback inhibited by histidine.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP phosphoribosyltransferase
- EC number
- Short namesATP-PRT ; ATP-PRTase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionD7WCS3
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-187 | ATP phosphoribosyltransferase catalytic | ||||
Sequence: RPKDIAIYVAGGHLDLGITGRDLMLDSRADVEEILDLGFGGSTFRFAAPADVAESMTIADLEGKRLATSYPHLAADYLADRGINAEVIRLDGAVEIAIKLGVADAIADVVSTGATLHQQGLAPFGEPIVASEAIVVKRT | ||||||
Domain | 208-278 | Histidine biosynthesis HisG C-terminal | ||||
Sequence: AHNFVMLDYNVSRDNLQSAVDITPGLTGPTVSPLQRENWVAVRAMVPRKEANLLMDRLAAAGAEAILASEL |
Sequence similarities
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length283
- Mass (Da)30,163
- Last updated2010-10-05 v1
- ChecksumFE368A0FF3B321F9
Keywords
- Technical term