D7S0P9 · D7S0P9_9INFA

Function

function

Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

1759100200300400500600700
TypeIDPosition(s)Description
Site627Mammalian adaptation

GO annotations

AspectTerm
Cellular Componenthost cell mitochondrion
Cellular Componenthost cell nucleus
Cellular Componentvirion component
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Biological Process7-methylguanosine mRNA capping
Biological Processcap snatching
Biological ProcessDNA-templated transcription
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Biological Processsymbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
Biological Processviral RNA genome replication
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polymerase basic protein 2
  • Alternative names
    • RNA-directed RNA polymerase subunit P3

Gene names

    • Name
      PB2

Organism names

  • Taxonomic identifier
  • Strain
    • A/swine/Guangdong/09/2008
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus

Accessions

  • Primary accession
    D7S0P9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain1-36Influenza RNA polymerase PB2 N-terminal region
Domain37-104Influenza RNA polymerase PB2 second
Domain107-248Influenza RNA polymerase PB2 middle
Domain250-319Polymerase basic protein 2 helical
Domain320-530Influenza RNA polymerase PB2 CAP binding
Domain531-678Influenza RNA polymerase PB2 sixth
Domain683-757Influenza RNA polymerase PB2 C-terminal
Motif736-739Nuclear localization signal

Sequence similarities

Belongs to the influenza viruses PB2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    759
  • Mass (Da)
    85,806
  • Last updated
    2010-08-10 v1
  • Checksum
    2ED74A001C72A6A6
MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIIETIPERNEQGQTLWSRMNDAGSDRVMVSPLAVTWWNRNGPTASTIHYPKVYRTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSSKEAQDVIMEVVFPNEVGARILTSESQLMITKKKKEELQECKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGACWEQLYTPGGEVRNDDVDQSLIIAARSIVRRATVSADPLASLLEMCHSTQIGGIRMVDILKQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSTKRDEEVLTGNLQTLKIRVHEGYEEFTLVGKRATAILRKATRRLVQLIVSGKDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGVESIDNVMGMIGILPDLTPSTEKSMRGIRISKMGVDEYSSTEKVVVSIDRFLRVKDQQGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILIRGNSPVFNYNKGTKRLTVLGKDAGVLNEDPDEGTSGVESAVLRGFLILGREDKRYGPALSINELSSLAKGEKTNVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM215174
EMBL· GenBank· DDBJ
ADH83312.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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