D7S0P9 · D7S0P9_9INFA
- ProteinPolymerase basic protein 2
- GenePB2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids759 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 627 | Mammalian adaptation | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell mitochondrion | |
Cellular Component | host cell nucleus | |
Cellular Component | virion component | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | 7-methylguanosine mRNA capping | |
Biological Process | cap snatching | |
Biological Process | DNA-templated transcription | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity | |
Biological Process | symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity | |
Biological Process | viral RNA genome replication | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePolymerase basic protein 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus
Accessions
- Primary accessionD7S0P9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-36 | Influenza RNA polymerase PB2 N-terminal region | ||||
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS | ||||||
Domain | 37-104 | Influenza RNA polymerase PB2 second | ||||
Sequence: GRQEKNPALRMKWMMAMKYPITADKRIIETIPERNEQGQTLWSRMNDAGSDRVMVSPLAVTWWNRNGP | ||||||
Domain | 107-248 | Influenza RNA polymerase PB2 middle | ||||
Sequence: STIHYPKVYRTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSSKEAQDVIMEVVFPNEVGARILTSESQLMITKKKKEELQECKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGACWEQLYTPGG | ||||||
Domain | 250-319 | Polymerase basic protein 2 helical | ||||
Sequence: VRNDDVDQSLIIAARSIVRRATVSADPLASLLEMCHSTQIGGIRMVDILKQNPTEEQAVDICKAAMGLRI | ||||||
Domain | 320-530 | Influenza RNA polymerase PB2 CAP binding | ||||
Sequence: SSSFSFGGFTFKRTSGSSTKRDEEVLTGNLQTLKIRVHEGYEEFTLVGKRATAILRKATRRLVQLIVSGKDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGVESIDNVMGMIGILPDLTPSTEKSMRGIRISKMGVDEYSSTEKVVVSIDRFLRVKDQQGNVLLSPEEVSETQGTEKLTIT | ||||||
Domain | 531-678 | Influenza RNA polymerase PB2 sixth | ||||
Sequence: YSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILIRGNSPVFNYNKGTKRLTVLGKDAGVLNED | ||||||
Domain | 683-757 | Influenza RNA polymerase PB2 C-terminal | ||||
Sequence: TSGVESAVLRGFLILGREDKRYGPALSINELSSLAKGEKTNVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA | ||||||
Motif | 736-739 | Nuclear localization signal | ||||
Sequence: KRKR |
Sequence similarities
Belongs to the influenza viruses PB2 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length759
- Mass (Da)85,806
- Last updated2010-08-10 v1
- Checksum2ED74A001C72A6A6