D7RVB4 · D7RVB4_RABIT
- ProteinNitric oxide synthase
- GeneNOS3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1209 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions.
Catalytic activity
- H+ + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP+ + 2 nitric oxideThis reaction proceeds in the forward direction.
CHEBI:15378 + 2 CHEBI:32682 + 3 CHEBI:57783 + 4 CHEBI:15379 = 4 CHEBI:15377 + 2 CHEBI:57743 + 3 CHEBI:58349 + 2 CHEBI:16480
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD.
Note: Binds 1 FMN.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | Golgi apparatus | |
Molecular Function | actin monomer binding | |
Molecular Function | arginine binding | |
Molecular Function | calmodulin binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | FMN binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | nitric-oxide synthase activity | |
Molecular Function | tetrahydrobiopterin binding | |
Biological Process | arginine catabolic process | |
Biological Process | endothelial cell migration | |
Biological Process | nitric oxide biosynthetic process | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | positive regulation of blood vessel endothelial cell migration | |
Biological Process | regulation of systemic arterial blood pressure by endothelin | |
Biological Process | removal of superoxide radicals | |
Biological Process | response to fluid shear stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNitric oxide synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionD7RVB4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-77 | Disordered | ||||
Sequence: MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPASPPPTPPAPDHSPKPSSNSPPLTRPPEGPKFPRV | ||||||
Compositional bias | 35-71 | Pro residues | ||||
Sequence: APEPSRAPASPPPTPPAPDHSPKPSSNSPPLTRPPEG | ||||||
Domain | 526-709 | Flavodoxin-like | ||||
Sequence: ATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAF | ||||||
Domain | 762-1008 | FAD-binding FR-type | ||||
Sequence: RKMFQATVLSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPPTEPVAVEQLEKGSPGGPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSIYPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLP | ||||||
Region | 824-853 | Disordered | ||||
Sequence: EDPPPPTEPVAVEQLEKGSPGGPPPSWVRD |
Sequence similarities
Belongs to the NOS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,209
- Mass (Da)133,823
- Last updated2010-08-10 v1
- Checksum71D90334D401F044
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 35-71 | Pro residues | ||||
Sequence: APEPSRAPASPPPTPPAPDHSPKPSSNSPPLTRPPEG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAGW02062500 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
HM135204 EMBL· GenBank· DDBJ | ADH93500.1 EMBL· GenBank· DDBJ | mRNA |