D7RU67 · D7RU67_9INSE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Ephemeroptera > Pisciforma > Baetidae > Callibaetis

Accessions

  • Primary accession
    D7RU67

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-49Helical
Transmembrane69-89Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-121Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    121
  • Mass (Da)
    12,848
  • Last updated
    2010-08-10 v1
  • Checksum
    8781656CD1B05A7D
SLLIRAELGNPGSLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLALLVSSSLVDVGAGTGWTVYPPLAANIAHGGSSVDFAIFSLHLAG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue121

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM130092
EMBL· GenBank· DDBJ
ADH15696.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130094
EMBL· GenBank· DDBJ
ADH15698.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130095
EMBL· GenBank· DDBJ
ADH15699.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130096
EMBL· GenBank· DDBJ
ADH15700.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130098
EMBL· GenBank· DDBJ
ADH15702.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130099
EMBL· GenBank· DDBJ
ADH15703.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130100
EMBL· GenBank· DDBJ
ADH15704.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130101
EMBL· GenBank· DDBJ
ADH15705.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130102
EMBL· GenBank· DDBJ
ADH15706.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130103
EMBL· GenBank· DDBJ
ADH15707.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130104
EMBL· GenBank· DDBJ
ADH15708.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130105
EMBL· GenBank· DDBJ
ADH15709.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130106
EMBL· GenBank· DDBJ
ADH15710.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130107
EMBL· GenBank· DDBJ
ADH15711.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130108
EMBL· GenBank· DDBJ
ADH15712.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130110
EMBL· GenBank· DDBJ
ADH15714.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130111
EMBL· GenBank· DDBJ
ADH15715.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130113
EMBL· GenBank· DDBJ
ADH15717.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130114
EMBL· GenBank· DDBJ
ADH15718.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130115
EMBL· GenBank· DDBJ
ADH15719.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130116
EMBL· GenBank· DDBJ
ADH15720.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130117
EMBL· GenBank· DDBJ
ADH15721.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130118
EMBL· GenBank· DDBJ
ADH15722.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130122
EMBL· GenBank· DDBJ
ADH15726.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130124
EMBL· GenBank· DDBJ
ADH15728.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130126
EMBL· GenBank· DDBJ
ADH15730.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130127
EMBL· GenBank· DDBJ
ADH15731.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130128
EMBL· GenBank· DDBJ
ADH15732.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130131
EMBL· GenBank· DDBJ
ADH15735.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130133
EMBL· GenBank· DDBJ
ADH15737.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130134
EMBL· GenBank· DDBJ
ADH15738.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130135
EMBL· GenBank· DDBJ
ADH15739.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130138
EMBL· GenBank· DDBJ
ADH15742.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130139
EMBL· GenBank· DDBJ
ADH15743.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130140
EMBL· GenBank· DDBJ
ADH15744.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130141
EMBL· GenBank· DDBJ
ADH15745.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130142
EMBL· GenBank· DDBJ
ADH15746.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130143
EMBL· GenBank· DDBJ
ADH15747.1
EMBL· GenBank· DDBJ
Genomic DNA
HM130144
EMBL· GenBank· DDBJ
ADH15748.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help