D7RU67 · D7RU67_9INSE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids121 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Ephemeroptera > Pisciforma > Baetidae > Callibaetis
Accessions
- Primary accessionD7RU67
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-49 | Helical | |||
Transmembrane | 69-89 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length121
- Mass (Da)12,848
- Last updated2010-08-10 v1
- Checksum8781656CD1B05A7D
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 121 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM130092 EMBL· GenBank· DDBJ | ADH15696.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130094 EMBL· GenBank· DDBJ | ADH15698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130095 EMBL· GenBank· DDBJ | ADH15699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130096 EMBL· GenBank· DDBJ | ADH15700.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130098 EMBL· GenBank· DDBJ | ADH15702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130099 EMBL· GenBank· DDBJ | ADH15703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130100 EMBL· GenBank· DDBJ | ADH15704.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130101 EMBL· GenBank· DDBJ | ADH15705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130102 EMBL· GenBank· DDBJ | ADH15706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130103 EMBL· GenBank· DDBJ | ADH15707.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130104 EMBL· GenBank· DDBJ | ADH15708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130105 EMBL· GenBank· DDBJ | ADH15709.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130106 EMBL· GenBank· DDBJ | ADH15710.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130107 EMBL· GenBank· DDBJ | ADH15711.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130108 EMBL· GenBank· DDBJ | ADH15712.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130110 EMBL· GenBank· DDBJ | ADH15714.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130111 EMBL· GenBank· DDBJ | ADH15715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130113 EMBL· GenBank· DDBJ | ADH15717.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130114 EMBL· GenBank· DDBJ | ADH15718.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130115 EMBL· GenBank· DDBJ | ADH15719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130116 EMBL· GenBank· DDBJ | ADH15720.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130117 EMBL· GenBank· DDBJ | ADH15721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130118 EMBL· GenBank· DDBJ | ADH15722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130122 EMBL· GenBank· DDBJ | ADH15726.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130124 EMBL· GenBank· DDBJ | ADH15728.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130126 EMBL· GenBank· DDBJ | ADH15730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130127 EMBL· GenBank· DDBJ | ADH15731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130128 EMBL· GenBank· DDBJ | ADH15732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130131 EMBL· GenBank· DDBJ | ADH15735.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130133 EMBL· GenBank· DDBJ | ADH15737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130134 EMBL· GenBank· DDBJ | ADH15738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130135 EMBL· GenBank· DDBJ | ADH15739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130138 EMBL· GenBank· DDBJ | ADH15742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130139 EMBL· GenBank· DDBJ | ADH15743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130140 EMBL· GenBank· DDBJ | ADH15744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130141 EMBL· GenBank· DDBJ | ADH15745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130142 EMBL· GenBank· DDBJ | ADH15746.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130143 EMBL· GenBank· DDBJ | ADH15747.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM130144 EMBL· GenBank· DDBJ | ADH15748.1 EMBL· GenBank· DDBJ | Genomic DNA |