D7GIX6 · D7GIX6_PROFC
- ProteinNADH-quinone oxidoreductase subunit B
- GenenuoB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids185 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + 5 H+(in) + NADH = a quinol + 4 H+(out) + NAD+
CHEBI:132124 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = CHEBI:24646 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane respiratory chain complex I | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | iron ion binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Molecular Function | quinone binding | |
Biological Process | aerobic respiration | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit B
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Propionibacteriaceae > Propionibacterium
Accessions
- Primary accessionD7GIX6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-145 | NADH:ubiquinone oxidoreductase-like 20kDa subunit | ||||
Sequence: CCAIEMISYGGPRADCSRWGQEIFRASPRQADLMIVAGRVGQKLAPVVRQLWDQMPNPKWCIAMGACASSGGVFNNYAVVQGVDHIVPVDMYLPGCPPRPDMLIDAVFK |
Sequence similarities
Belongs to the complex I 20 kDa subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length185
- Mass (Da)20,311
- Last updated2010-08-10 v1
- Checksum45AE72FD45294C58
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FN806773 EMBL· GenBank· DDBJ | CBL56048.1 EMBL· GenBank· DDBJ | Genomic DNA |