D7GFD4 · D7GFD4_PROFC

Function

function

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondamaged DNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity
Biological Processregulation of DNA-templated transcription
Biological Processtranscription-coupled nucleotide-excision repair, DNA damage recognition

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription-repair-coupling factor
  • EC number
  • Short names
    TRCF

Gene names

    • Name
      mfd
    • Ordered locus names
      PFREUD_17350

Organism names

Accessions

  • Primary accession
    D7GFD4

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region366-385Disordered
Domain664-825Helicase ATP-binding
Domain843-1000Helicase C-terminal
Region1210-1232Disordered

Sequence similarities

In the C-terminal section; belongs to the helicase family. RecG subfamily.
In the N-terminal section; belongs to the UvrB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,232
  • Mass (Da)
    134,359
  • Last updated
    2010-08-10 v1
  • Checksum
    83FBBE5BA3157BB0
MMLQGLIDTVCNDPAIADAIEQARAGVPALDIAGPPATRAFITSGLVRRAGRPLLVVTSTFREAESLVDELSSLLGDEEVAYYPAWETLPHERLSPNSDTVGHRLEVLRRIAGKDDLPAPSVVVAPIRSVLQPQVRGLADLPVVKLRTAEDYDPSRLEADLVAAAYSRVDLVERRGEFAVRGGIVDIFAPTYSHPVRVDFFGDTIEDLRFFTVGDQRSTDETVDEFVAAPCRELLITPEVQQRAAALVDAHPELSEMLEKISQGQSVEGMEALIPALADGVELLVDVMAPETLTLVCDPELVRTRAADLVRTSQEFLHASWAAAAAGGKAPIDLAASSYQELADVRQHSLDIGQGWWSLSAFAAAPDSAPQGEDPTGESASAGESVSAADAAFAGGIPEMILDMEPLPGWRGDAEKAIATMTDDLARGWRVVSSVEGKGLANRMAEMLRDHDTPARVLDELPDEPEPHVVSIILSGLRHGFRAPDLKLTLVAAGDITNQPNADRSSRKMPTKRRNQVVPLELKPGDPLVHEQHGVGRFVEMTQRTVAGAIREYMVIEYAASKRGQPGDRLYVPMDQLDQVTRYVGGEAPALDKMGGAEWKHRKSRARKAVRQVAAGLIKLYAARQASRGHAFSPDTPWQHEMEDAFRYEETPDQLACITDVKHDMEQIVPMDRLICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLVQQHYQTFAERYSGFPVTVAQLSRFQTEKEVATTLEEMAQGKVDVVIGTHRLLSSKVHYKDLGLVIIDEEQRFGVEHKEALKKLRVNVDVLSMSATPIPRTLEMAVTGIREMSTITTPPEERHPVLTFAGPYDEGQVVAAIRREMAREGQVFLVHNRVASIDRVAARIREMVPEARVVTAHGQMSEKTLEKVMVDFWERRADVLVCTTIVEAGLDIPTANTLIVDRADHMGLSQMHQLRGRVGRSRERGYAYFLYPGDRTLTTTAHDRLAALAANNELGAGMAIAMKDLEIRGAGNLLGDEQSGHIADVGFDLYLRLVGEAVAEFKGDGPGEEEKPMRIELPVNAHLPEDYVESERLRLEMYKRIAEVTSTDDIEALRGELQDRYGPVPEQAESLLTVAAFRLLCRQAGLTEVMSQGRSIRFAPIAGRRAPDGTELSLPDSRRVRLDRLYPGTLVKNAANLALVPAPRTAKVGGQPIIGDELIAWASGFVRDILLPDAPRRQGTAGNTAGDTVGATAGAAAG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN806773
EMBL· GenBank· DDBJ
CBL57245.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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