D7B412 · MSHC_NOCDD

Function

function

Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site43Zn2+ (UniProtKB | ChEBI)
Binding site43-46L-cysteinyl-5'-AMP (UniProtKB | ChEBI)
Binding site58L-cysteinyl-5'-AMP (UniProtKB | ChEBI)
Binding site81-83L-cysteinyl-5'-AMP (UniProtKB | ChEBI)
Binding site223L-cysteinyl-5'-AMP (UniProtKB | ChEBI)
Binding site227Zn2+ (UniProtKB | ChEBI)
Binding site245-247L-cysteinyl-5'-AMP (UniProtKB | ChEBI)
Binding site252Zn2+ (UniProtKB | ChEBI)
Binding site278L-cysteinyl-5'-AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioncysteine-glucosaminylinositol ligase activity
Molecular Functioncysteine-tRNA ligase activity
Molecular Functionzinc ion binding
Biological Processcysteinyl-tRNA aminoacylation
Biological Processmycothiol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
  • EC number
  • Short names
    L-Cys:GlcN-Ins ligase
  • Alternative names
    • Mycothiol ligase
      (MSH ligase
      )

Gene names

    • Name
      mshC
    • Ordered locus names
      Ndas_1544

Organism names

Accessions

  • Primary accession
    D7B412

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004004731-407L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif.

Type
IDPosition(s)Description
Region1-22Disordered
Motif45-55'HIGH' region
Motif183-188'ERGGDP' region
Motif284-288'KMSKS' region

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    407
  • Mass (Da)
    43,789
  • Last updated
    2010-08-10 v1
  • Checksum
    7DA07DDA4E548DEE
MRSWSAPDIVPLPGTGGPLRVHDTATGRIRTTTPGPRAGMYACGITPYDAAHLGHAFTYLTFDLVNRVWRDAGHDVNYVQNTTDIDDPLLERAEATGVDWRDLAHREIDVFREDMAALRIIPPTSYVGVVESVDLISDLAARIRDTGAAYELDGDLYFSVAEAPEFGEISNLDRGQMLELFGERGGDPQRTGKKDPLDWLLWRAERPGEPAWDSPLGRGRPGWHIECSAIALDRLGPAFDLNGGGSDLIFPHHEMGAAETRCATGGPNAHNHLHVGMVGLDGEKMSKSLGNLVFVSKLRQQGVDPAVIRLAMLAHHYRAPWEWTDAELPAATARAERWRSALALGAAPDAAPVLAAVRAALSEDLDSPAALAAVDAWADTALTEGGADTGAPALVRATVDTLLGVRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002040
EMBL· GenBank· DDBJ
ADH66973.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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