D6ZY72 · D6ZY72_BIFLJ

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12substrate
Active site74Proton acceptor
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75substrate
Binding site193-196substrate
Binding site230substrate
Binding site235-236substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      BLJ_0386

Organism names

Accessions

  • Primary accession
    D6ZY72

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region202-227Disordered

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    26,448
  • Last updated
    2010-08-10 v1
  • Checksum
    A14436A66D6E46C8
MQIVVATHNEGKLVEIRRILEEDLGADAENIELVSAGSLHLPDPVETGVTFQENALLKARAVAIRTGLPAVADDSGLIVDVMGNAPGILSARWAGAHGHDKANNALLLAQIEDIPDDKRTARFRCAAALVVPDAEASADVTGGVAADGITVYTTAADGSTAPVHARYAIKSETVELGDMPGRIIREARGEHGFGYDPLFVPDDQPAGRVSTEPDHEGEPLTSAEMTPAEKNAISHRGKALKALVPAIEALLH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002010
EMBL· GenBank· DDBJ
ADG99868.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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