D6WUN4 · D6WUN4_TRICA
- ProteinOxidized purine nucleoside triphosphate hydrolase
- GeneAUGUSTUS-3.0.2_06761
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids179 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Catalytic activity
- 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+This reaction proceeds in the forward direction.
- 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+This reaction proceeds in the forward direction.
- 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+This reaction proceeds in the forward direction.
- N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+This reaction proceeds in the forward direction.
- N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+This reaction proceeds in the forward direction.
- O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA protection |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxidized purine nucleoside triphosphate hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionD6WUN4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length179
- Mass (Da)20,527
- Last updated2010-08-10 v1
- Checksum02AE18A31A015D81
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ971363 EMBL· GenBank· DDBJ | EFA09048.1 EMBL· GenBank· DDBJ | Genomic DNA |